Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, despite the importance of plant derived natural products, metabolic engineerin...

Every year over 1.5 million men develop prostate cancer and it is also a significant cause of mortality among men. There are multiple factors upregulating cancer, which includes mutation in the genetics, ethnicity or hereditary. Out 23 MMPs, there 4 MMPs mostly upregulated cancer. function by deteriorating several proteins present extracellular matrix. Catharanthus roseus medicinal plant has an...

The effects of varying irrigation intervals (I) and foliar application of salicylic acid (M) on morphological and physiological traits of Catharanthus roseus L. were studied in a factorial experiment based on a randomized complete block design with three replications. The experimental treatments consisted of four irrigation intervals [2 days (I1), 4 days (I2), 6 d...

The natural product class of iridoids, found in various species of flowering plants, harbors astonishing chemical complexity. The discovery of iridoid biosynthetic genes in the medicinal plant Catharanthus roseus has provided insight into the biosynthetic origins of this class of natural product. However, not all iridoids share the exact five- to six-bicyclic ring scaffold of the Catharanthus i...