PURPOSE To study the effect of cyclosporin (CsA) on steroid-induced cataracts in patients following renal transplantation. METHODS The subjects comprise 140 patients who had undergone renal transplantation at Kanazawa Medical Hospital. These subjects had received ophthalmologic examinations prior to their surgery and subsequently over the span of 12 months following surgery. The charts of the...

Although uncommon, the occurrence of cataracts in very young patients can result in significant impairment—and can lead to blindness. This practical guide delivers need-to-know information to help clinicians treat pediatric patients with cataracts with a range of therapies and essential guidance on the management of complications. Explore the only reference devoted exclusively to pediatric cata...

A novel missense mutation in the gene for gap-junction protein α3 (GJA3) associated with autosomal dominant " nuclear punctate " cataracts linked to chromosome 13qA novel missense mutation in the gene for gap-junction protein α3 (GJA3) associated with autosomal dominant " nuclear punctate " cataracts linked to chromosome 13q.

PURPOSE To report the identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea. METHODS We investigated a four-generation Chinese family with six members affected with nuclear cataracts and microcornea. The family resides in a relatively isolated region of northern China. Genomic DNA was isolated from blood l...

BACKGROUND Anterior lens opacities (ALO) are found in 3-14% of pediatric patients with cataracts. No clear guidelines exist in the management and treatment of these cataracts. OBJECTIVE To evaluate pediatric patients with anterior lens opacities and assess rate of amblyopia and need for surgery over time. METHODS A retrospective chart review was performed on patients with unilateral and bil...

INTRODUCTION To evaluate whether eyes with longer axial lengths are associated more often with clinically significant cataracts than eyes with shorter axial lengths. MATERIAL AND METHODS Charts of consecutive patients who underwent cataract surgery by 4 resident surgeons at Los Angeles County Hospital from July 2001 through May 2002 were retrospectively reviewed. Those patients whose axial le...

C ataract results from a loss in transparency of the crystalline lens. Worldwide, there are an estimated 20 million people blind (Snellen visual acuity of 3/60 or less) as a result of cataract. Despite effective surgical treatment, demand outstrips supply in both Western and developing countries, for many reasons, 3 and other disease modifying strategies must be considered. A strong genetic pre...

In the rabbit, cryoextraction of the lens and subsequent storage in Tyrode's solution did not alter the Na,K-ATPase activity from that determined in immediately excised rabbit lenses. Similarly, the procedures employed with the rabbit eye to simulate collection and storage of normal human eyes (eye banking) had no effect upon the Na,K-ATPase activity of the lens. These results permitted the inv...

PURPOSE Cataracts can be broadly divided into two types: congenital cataracts and age-related cataracts. DeltaG91 is a previously discovered congenital mutation in betaA3-crystallin that impairs protein solubility. On the other hand, the deamidation of beta-crystallin is a significant feature in aged and cataractous lenses. Several deamidation sites were also identified in betaA3-crystallin. Th...

Early-onset cataracts are associated with insufficient antioxidative activity, and, therefore, a potential risk of cancer. This study investigated the risk of cancer after being diagnosed with early-onset cataracts. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Study subjects were comprised of patients with early-onset cataracts, aged 20-55...