OBJECTIVES: Cardiovascular risk is increased in patients with systemic lupus erythematosus (SLE). Drugs used to treat SLE can modify traditional cardiovascular risk factors. We examined the effect of selected drugs used in the treatment of SLE on cardiovascular risk factors. METHODS: We compared systolic and diastolic blood pressure, serum lipid concentrations, glucose, homocysteine, and urinar...

Inhibitors of cyclo-oxogenase (COX) are widely used anti-inflammatory drugs. In recent years concerns have arisen about the cardiovascular safety of these drugs, initially because of reported associations between therapy with the COX-2 selective inhibitor rofecoxib and myocardial infarction. However, subsequent data have suggested an association between therapy with non-selective COX inhibitors...

Cancer represents the second cause of death in European Union after cardiovascular diseases, accounting for 27% all deaths. Anticancer drugs (ACDs) have poor cell selectivity and a narrow therapeutic margin, such way that small increases their plasma levels lead to appearance adverse reactions multiple tissues. The FACs can produce wide range (named cardiotoxicity) increase morbidity even some ...

This review presents a summary of reactions that take place during the “Leuckart-type reaction”. The significance of, as well recent advancements in, synthesis amines through simple and inexpensive methods using readily available raw materials is discussed. includes all catalytic noncatalytic involve Leuckart method. Recent studies have shown at least quarter C–N bond-forming in pharmaceutical ...