Objective(s): Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002. It belongs to the thiazolidinedione group which some of its members have been withdrawn from the market due to the hepatotoxicity or cardiotoxic...

Doxorubicin is Anrthacycline derivative and most active cytotoxic agent in current use. It is been using to treat various malignancies but the clinical usefulness has been limited due to its specific cardiac toxicity. The main objective is to study the preventive role of ethanolic extract of whole plant of Boerhaavia diffusa (EEBD) against doxorubicin (Dox) induced myocardial toxicity in rats. ...

Excessive reverse-mode (RM) sodium/calcium exchanger 1.1 (NCX1.1) activity, resulting from intracellular sodium accumulation caused by reduced Na+/K+-ATPase activity, increased Na-H exchanger 1 activity. The induction of the voltage-gated sodium channel late current component (late INa), is a major pathway for intracellular calcium (Ca2+i) loading in cardiac ischemia-reperfusion (IR) injury and...

BACKGROUND Hodgkin disease (HD) and medulloblastoma (MB) are common malignancies found in children and young adults, and radiotherapy is part of the standard treatment. It was reported that these patients who received radiation therapy have an increased risk of cardiovascular late effects. We compared the predicted risk of developing radiogenic cardiac toxicity after photon versus proton radiot...

Costs of defense are thought to maintain genetic variations in the expression of defense within plant populations. As with many plant species, aspen exhibits considerable variation in allocation to secondary metabolites. This study examined the independent and interactive effects of genotype, soil fertility and belowground competition on defensive chemistry and growth in trembling aspen (Populu...

t-wave oversensing occurs when the counter starts giving dual beeps for every cardiac cycle instead of one. this usually happens when the monitoring lead displays a tall t wave, which is also sharp. r wave sensing algorithms of the devices do not sense t wave because the slow rate of the t wave is much less than that of the r wave. but the slow rate of t waves may change with time and also beca...