Cardiac ischemia and reperfusion (I/R) injury remains a challenge for clinicians. Ginsenoside Rb1 (Rb1) has been reported to have the ability to attenuate I/R injury, but its effect on energy metabolism during cardiac I/R and the underlying mechanism remain unknown. In this study, we detected the effect of Rb1 on rat myocardial blood flow, myocardial infarct size, cardiac function, velocity of ...

Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, Sprague-Dawley rats were randomized to undergo sham or subtotal nephrectomy (SNx) surgery. At 3 weeks post surgery, SNx animals were further random...

BACKGROUND To investigate the effects and involved mechanisms of the modified Yi Qi decoction (MYQ) in cardiac ischemia-reperfusion (IR) induced injury. METHODS Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by reperfusion, low or high dose decoction of MYQ was administrated orally for 1 week or 1 month. RESULTS Both in 1 week and 1 month IR rat gro...

Background Recent evidence supports the existence of a trauma induced secondary cardiac injury (TISCI) that is associated with poor clinical outcome [1]. Cardiac dysfunction has been demonstrated as early as 30mins after injury and is characterised by reduced contractility that is unresponsive to increased perfusion and preload [2].Inflammation is implicated as a key aetiological factor [1,3]. ...

Background Firearm – related injuries of the thorax and heart are a major problem worldwide. Mortality rate in non-cardiac thoracic injuries is very low compared with that of cardiac injury. Because of the complexity of the injury a gunshot wound to the heart has the highest mortality rate. The rate of thoracic aorta injuries is burdened with a high mortality (80-90%) and management of this inj...

Brachial Plexus Injury (BPI) is an uncommon complication of median sternotomy capable of causing a permanent or transitory sensitivity and/or motor function impairment in the upper limbs. During a cardiac surgery through sternotomy, for the assessment of the thoracic cage configuration and the site of mediastinal structures, a broader surgical field may be required. If the sternal retractors ar...

Acute kidney injury is a common and significant problem that occurs in a wide variety of clinical settings. Cardiac surgery-associated acute kidney injury continues to be a well-recognized complication of cardiac surgery with associated morbidity and mortality. A lack of early biomarkers for acute kidney injury has prevented timely interventions to mitigate the effects of acute kidney injury. B...

Introduction: The use of polyethylene glycol-based solutions is the gold standard for bowel preparation colonoscopy. However, glycol might be associated with risk acute kidney injury. We aim to find out injury and factors development in patients using colonoscopy.Materials Methods: This was an observational study conducted Department Nephrology Gastroenterology, Bir hospital. Patients who under...

AIMS Cardiac surgery and coronary angiography are both associated with risk of acute kidney injury (AKI). We hypothesized that the risk of post-operative AKI increases when coronary angiogram and cardiac surgery are performed in close succession, without sufficient time for recovery from the adverse effects of intravenous contrast. METHODS AND RESULTS We included 2133 consecutive patients who...