The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for inhibitors and identified small molecules that block in the low µM range. Furthermore, investigated pathophysiology cardiac conditions, immune diseases cancer using these novel inhibitors, mo...

Diastolic dysfunction of the heart is correlated with cardiac mortality. Serum cystatin C (CysC) is an endogenous marker of kidney function. It is not clear whether serum CysC is associated with diastolic dysfunction in patients with varying cardiac conditions with concomitant diastolic abnormalities and preserved ejection fraction (EF). The authors measured serum CysC levels in patients with c...

Introduction: Extreme weather or climate, including heat waves and cold waves, is considered a health issue causing adverse effects on health, such as cardiovascular diseases (CVDs), mortality and morbidity. Thus, this systematic review aimed to study the impacts of extreme ambient temperature on cardiovascular outcomes. Material and Methods: This study was carried out based on the Preferred R...

introduction: pneumonia is an inflammation of the parenchyma of the lungs. most cases of pneumonia are caused by microorganisms, but there are several non-infectious causes accordingly. pneumonia is a considerable cause of mortality in childhood, throughout the world, particularly in developing countries. this study, according to this important matter, evaluated & inspected all of the patients ...

The invention of beta (β)-blockers culminated in a new era in the treatment of cardiovascular diseases (CD), and changed the course of pharmacology research for years to come. Since the introduction of propranolol into clinical practice in 1964, β-blockers enjoyed a special place in the clinicians' armamentarium against CDs, especially for patients with ischemic heart diseases, and are still on...

Developmental genetics of congenital heart diseases has evolved from analysis of embryo sections towards molecular genetics of cardiac morphogenesis with a dynamic view of cardiac development. Lineage analysis, transgenic animal models and retrospective clonal analysis of the developing heart led to identification of different cardiac lineages and their respective roles. Genetics of congenital ...

The S100 protein family is the largest group of EF-hand signaling proteins in humans. The members of the S100 protein family are expressed in many tissues and play different functions. Many diseases are related to S100 proteins, which function as new biochemical markers especially in cardiac diseases. The most studied members, protein S100B and protein S100A1, exhibit activities in cardiac dise...

Abstract Purpose of Review Resistant hypertension (RH) is a major contributor to cardiovascular diseases and associated with increased all-cause mortality. Cardiac changes such as impaired left ventricular (LV) function, hypertrophy (LVH), myocardial fibrosis, enlarged atrium (LA) are consequences chronic exposure an elevated blood pressure. The purpose this review article demonstrate the poten...

In the present report we describe the results from a pilot study aimed at detecting enterovirus sequence in cardiac tissues, obtained through endomyocardial biopsies, from patients suffering from cardiac diseases in the Amazon region. Six samples that were collected from three patients were analysed by RT-PCR showing 3 positive and 3 negative results. These preliminary findings suggest the part...