STUDY OBJECTIVES To retest previous findings that childhood cancers are probably initiated by prenatal exposures to combustion process gases and to volatile organic compounds (VOCs); and to identify specific chemical hazards. DESIGN Birth and death addresses of fatal child cancers in Great Britain between 1966 and 1980, were linked with high local atmospheric emissions of different chemical s...

Only a very small number of the known substances is strongly carcinogenic. This indicates that carcinogenicity is linked to different qualities which all must be present to produce cancer. The various chemical reactions or qualities brought into relation with carcinogenicity reflect one or more of these factors. None of them seems to comprise all involved parameters. At the same time, none of t...

Introduction During the 30 years or so following the identification of the first pure chemical carcinogen (1), no common factors or pathways in the mechanism of action of carcinogens from different chemical classes were evident. For this reason perhaps, each class of carcinogen, e.g. the polycyclic aromatic hydrocarbons, the aromatic amines and the nitrosamines, was often reviewed and discussed...