1. Hydrogen cyanide inhibited acetoacetate decarboxylase only when incubated with the enzyme in the presence of car-bony1 compounds. This resulted in an inhibitory synergism between hydrogen cyanide and carbonyl compounds. This synergism was used to investigate the comparative abilities of various carbonyl compounds to form Schiff’s bases at the active site of the enzyme. The order of effective...

The considerable importance of ?-arylated carbonyl compounds, which are widely used in the pharmaceutical industry, has prompted efficient synthetic strategies for their preparation.

Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(ii) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in eithe...

Equilibria between carbonyl compounds and their enamines (from O-TBDPS-derived prolinol) have been examined by NMR spectroscopy in DMSO-d(6). By comparing the exchange reactions between pairs (enamine A + carbonyl B → carbonyl A + enamine B), a quite general scale of the tendency of carbonyl groups to form enamines has been established. Aldehydes quickly give enamines that are relatively more s...

The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over activity or abnormally low activity of the immune cells resulting in autoimmune or...