Increasing resistance to carbapenem antibiotics has become a particular concern. Combination therapy might constitute an effective way control drug-resistant bacterial infections. Here, we show that AuRh nanoparticles (NPs) have synergistic antibacterial effect with small-molecule antibiotic (imipenem), and they exhibit excellent efficacies by increasing intracellular reactive oxygen species le...

We investigated the presence of carbapenemases in carbapenem-resistant Pseudomonas aeruginosa isolates, which were collected over a 14-month period Turkish hospital, with in-depth molecular characterization carbapenemase-producing isolates. Among 45 study 2 isolates identified as carbapenemase producers by both Carba NP and Carbapenem Inactivation Method tests, only 1 them gave positive result ...

Carbapenem administration is an important therapy for nosocomial infections due to MDRO, especially Acinetobacter baumannii. The global increase in carbapenem-resistant A. baumannii (CRAB) that causes this pathogen has significantly threatened public health the lack of adequate treatment options very few currently available antimicrobial agents actively fight CRAB. Antimicrobial resistance a ma...

Results Rates of A. baumannii bacteraemia significantly increased between 2005 and 2009, from 0.1 to 3.2 cases/100,000 inhabitants per year. The observed increase was due to carbapenem-resistant isolates, while the number of carbapenem-susceptible isolates remained substantially stable over the study period. Importantly, the occurrence of carbapenem-resistant isolates showed a steep five-fold i...

Carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter spp., and Enterobacteriaceae pose urgent public health threats. The differential burden, relative risks, associations with antimicrobial consumption, and temporal trends of those taxa in large, geographically diverse U.S. health systems remain under reported. Electronic records of all patients in a geographically dispersed 280-hospital ...

OBJECTIVE We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. METHODS Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABAC...

Carbapenems are a class of last-resort antibiotics; thus, the increase in bacterial carbapenem-resistance is a serious public health threat. Acinetobacter baumannii is one of the microorganisms that can acquire carbapenem-resistance; it causes severe nosocomial infection, and is notoriously difficult to control in hospitals. Recently, a machine-learning approach was first used to analyze the ge...

INTRODUCTION Colistin use has increased over the last ten years because of multidrug-resistant microorganisms. The aim of this study was to compare the clinical and microbiological efficacy of colistin alone or in combination with sulbactam or carbapenem in the treatment of ventilator-associated pneumonia (VAP) due to multidrug-resistant (MDR) and extremely drug-resistant (XDR) A. baumannii. ...

BACKGROUND Carbapenem-resistant Acinetobacter baumannii poses a significant threat to hospitalized patients, as few therapeutic options remain. Thus, we investigated the molecular epidemiology and mechanism of resistance of carbapenem-resistant A.baumannii isolates in Beijing, China. METHODS Carbapenem-resistant A.baumannii isolates (n = 101) obtained between June 2009 and November 2014 were ...