The use of CAR+ T cells for the treatment of cancer is growing as multiple centers participate in Phase I/II clinical trials. Prior studies of CAR-dependent T cell effector function evaluated CAR design on T-cell responses in vitro and in vivo. Our study assesses the effect ex vivo co-stimulation imparts on in vitro and in vivo effector function of CAR+ T cells. In this study, the well characte...

Car-following models are among the most important components of micro traffic flow simulation which is studiedby transportation experts to evaluate new applications of intelligent transportation systems. Until now, several carfollowingmodels have been proposed. An obvious disadvantage of the former models is the great number of parameterswhich are difficult to calibrate. In th...

This paper presents a stochastic driver behavior modeling framework which takes into account both individual and general driving characteristics as one aggregate model. Patterns of individual driving styles are modeled using a Dirichlet process mixture model, as a non-parametric Bayesian approach which automatically selects the optimal number of model components to fit sparse observations of ea...

In this paper, a scheme of moving-vehicles behavior detection based on accelerometer is proposed. Three-axis accelerometers are installed on vehicles to capture the moving car postures. A fuzzy interpretation system is developed to infer states of vehicle posture, such as normal driving, left/right turning, departure, accelerate, braking and bumping. Based on the appreciation of vehicle posture...

Vehicles in the foreseeable future will be required to transition between autonomous driving (without human involvement) and full human control. During this transition period, the human, who has not been actively engaged in the driving process, must resume the motor control necessary to steer the car. The in-car study presented here demonstrates that when human drivers are presented with a stee...

Car horns were originally installed in vehicles for safety. However, many urban areas several countries face noise problems related to the use of car and motorbike horns. To propose measures suppress horns, relationships between horn factors including driver awareness behavior, traffic environment, transportation system should be investigated. The present study therefore conducted surveys grasp...

background: motor vehicle crashes (mvc) are considered to be the most common safety challenge, causing more than a million deaths worldwide annually. objectives: the current study was aimed at identifying the etiological role of human and vehicle safety factors in road crashes, and their effects on the severity of injury and fatality in the sistan and baluchistan province, south east iran. pati...

We study numerically the behavior of the Biham-Middleton-Levine traffic model in three dimensions. Our extensive numerical simulations show that the phase diagram for this model in three dimensions is markedly different from that in one and two dimensions. In addition to the full speed moving as well as the completely jamming phases, whose respective average asymptotic car speeds (v) equal one ...

The aim of the article is to present preliminary results obtained by analysis of the behavior patterns of various driver subjects, in the context of an intelligent assistive driving system. We determined the parameters which are involved in determining the car driver’s interaction intent, and extracted features of interest from various measured parameters of the driver, car, and the environment...