Sterilization is a quite challenging step in the development of novel polymeric scaffolds for regenerative medicine since conventional sterilization techniques may significantly alter their morphological and physicochemical properties. Supercritical (sc) sterilization, i.e. use scCO2 as sterilizing agent, emerges promising method due to mild operational conditions excellent penetration capabili...

Tuberculosis remains one of the major health problems worldwide. Besides lungs, tuberculosis affects other organs, including bones and joints. In case bone tuberculosis, current treatment protocols include necrectomy in combination with conventional anti-tuberculosis therapy, followed by reconstruction resulting defects. this study, we compared autografting implantation a biodegradable composit...

Stem cell therapy has emerged as the most vibrant area of research, due to capacity stem cells for self-renewal and differentiation into different types lines upon their culture. But lately, scientists become increasingly aware limitations conventional 2D culture media, several key drawbacks associated with this model, such immune response transplantation, animal pathogen contamination, complic...

The random architecture of a commercial copolymer of poly(DL-lactic acid) and poly(ε-caprolactone), poly(DL-lactide-co-caprolactone), has been characterized by chemical structure analysis from hydrogen-1 nuclear magnetic resonance results. Moreover, spherical nanodomains have been detected in the thin films of this copolymer obtained after solvent evaporation. These nanodomains studied by atomi...

Recently, several thermogelling materials have been developed for biomedical applications. In this study, we prepared methoxy polyethylene glycol (MPEG)-b-(poly(ε-caprolactone)-ran-poly(2chloride-ε-caprolactone) (PCL-ran-PfCL)) (MP-Cl) diblock copolymers at room temperature via the ring-opening polymerization of caprolactone (CL) and 2-chloride-ε-caprolactone (fCL) monomers, using the terminal ...

Next-generation synthetic bone graft therapies will most likely be composed of resorbable polymers in combination with bioactive components. In this article, we continue our exploration of E1001(1k), a tyrosine-derived polycarbonate, as an orthopedic implant material. Specifically, we use E1001(1k), which is degradable, nontoxic, and osteoconductive, to fabricate porous bone regeneration scaffo...

Chronic inflammation-mediated oxidative stress is a common mechanism of implant rejection and failure. Therefore, polymer scaffolds that can degrade slowly in response to this environment may provide a viable platform for implant site-specific, sustained release of immunomodulatory agents over a long time period. In this work, proline oligomers of varying lengths (P(n)) were synthesized and exp...

The treatment of bone defects is facing the situation of lacking donations for autotransplantation. As a valid approach, scaffold-based tissue engineering combines the construction of well-defined porous scaffolds with advanced cell culturing technology to guide tissue regeneration. The role for the scaffold is to provide a suitable environment with a sufficient mechanical stiffness, supports f...

Nowadays, despite significant advances in the field of biomaterials for tissue engineering applications, novel bone substituents still need refinement so they can be successfully implemented into medical treatment fractures. Generally, a scaffold made synthetic polymer blended with nanofillers was proven to very promising biomaterial engineering, however choice components said remains questiona...