carvedilol is administered as a racemic mixture of the r(+)- and s(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. the aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. stereoselective interact...

abstract         background and objective: normal hemoglobin (hb) is formed of a heme group and a protein group known as globin. globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. cellulose acetate method is a common way to differentiate haemoglobinopathies. inability to identify the components of hb low co...

INTRODUCTION Haemoglobin saturation is an obligatory oxygen parameter in the assessment of neonatal oxygenation. Although, pulse oximetry is currently one of the major methods in the determination of haemoglobin saturation, capillary blood saturation is still present in the diagnostic process. As well known, haemoglobin saturation value of capillary blood is insufficiently accurate, but not as ...

BACKGROUND Preeclampsia is a major cause of maternal and neonatal mortality and morbidity. The incidence of preeclampsia seems to be rising because of increased prevalence of predisposing disorders, such as essential hypertension, diabetes, and obesity, and there is increasing evidence to suggest widespread microcirculatory abnormalities before the onset of preeclampsia. We hypothesized that qu...

NMR spectroscopy allows measurements of very accurate values of equilibrium dissociation constants using chemical shift perturbation methods, provided that the concentrations of the binding partners are known with high precision and accuracy. The accuracy and precision of these experiments are improved if performed using individual capillary tubes, a method enabling full automation of the measu...

The fabrication of three-dimensional (3D) diamond photonic crystals with controllable nanoroughness (≤120 nm) on the surface from epoxy-functionalized cyclohexyl polyhedral oligomeric silsesquioxanes (POSS) is reported. The nanoroughness is generated on the 3D network due to microphase separation of the polymer chain segments in a nonsolvent during the rinsing step in holographic lithography pr...

[Purpose] The present study examined the effects of wearing rubber gloves on the activities of the forearm and shoulder muscles during two dishwashing stages. [Subjects] This study included 10 young females. [Methods] The participants performed two dishwashing stages (washing and rinsing) with and without rubber gloves. The activities of the wrist flexor and upper trapezius muscles were measure...

Objective-To discover the cause of an outbreak of facial rash in a holiday centre. Design-Questionnaire survey of those with rash; analysis of samples of linen. Setting-Holiday centre in south west England. Patients-98 holidaymakers presenting to the first aid post with a facial rash. Intervention-Replacement of bed linen with new linen in selected parts of the site. Results-The attack rate was...

1) Skin or mucosal biopsy specimens are usually obtained by 3-5 mm punch or surgical biopsy. 2) Biopsy specimens are snap frozen. If there is a delay between biopsy and snap freezing, the specimen should be kept in cold saline. 3) Frozen 4-6μ sections are cut on a cryostat and placed on a glass slide before being air-dried for 15 minutes. 4) After rinsing in phosphate buffered saline (PBS), pH ...

Self-control is critical for achievement and well-being. However, people's capacity for self-control is limited and becomes depleted through use. One prominent explanation for this depletion posits that self-control consumes energy through carbohydrate metabolization, which further suggests that ingesting carbohydrates improves self-control. Some evidence has supported this energy model, but be...