We present a case of a 30-year old female patient presenting with acrocyanosis and nail changes (leukonychia, onycholysis), who has been treated with valproic acid for 3 years. Acrocyanosis, listed in the group of acrosyndromes, is a painless condition, characterized by symmetrical discoloration of various shades of blue colour, localized within the hands, feet and face, often associated with h...

Results Mean baseline FBF was significantly lower in JSS patients when compared to controls (204.5 ± 210.1 vs 649.6 ± 92.5 PU, p <0.002). There was also a trend towards lower mean baseline FBF in patients with JSS compared to patients with primary Raynaud’s phenomenon. We observed a sharp drop in average FBF 1 minute after the cold stimulus in all groups. The mean FBF remained significantly low...

Patients with Raynaud's phenomenon have abnormal digital vasoconstriction in response to cold. The pathogenesis remains unknown but may involve a local neurovascular defect leading to vasoconstriction. Diagnosis of primary Raynaud's phenomenon is based on typical symptomatology coupled with normal physical examination, normal laboratory studies and lack of observable pathology by nail fold capi...

Vascular acrosyndromes constitute a common reason for physician visits. They are associated with connective tissue disease; for example, 90% of patients with scleroderma experience Raynaud's phenomenon. The rheumatologist must strive to establish the diagnosis, to identify a potential underlying cause, and to prescribe effective treatment when the symptoms are incapacitating. Raynaud's phenomen...

Nailfold capillaroscopy (NC) allows non-invasive imaging of systemic sclerosis (SSc) related microvascular disease. We have developed a state-of-theart NC system that enables fast, panoramic imaging of the whole nailfold at highmagnification, and incorporates novel software to make fully automated estimates of capillary structure and blood flow velocity. We present the first results of a study ...

Background: The role of capillaroscopy for early diagnosis systemic sclerosis (SSc) is well-known and pathological capillaroscopic pattern a component the new set criteria SSc (EULAR/ACR 2013). While it also known that similar microvascular changes i.e., “scleroderma-like” could be observed in other rheumatic diseases undifferentiated connective tissue disease (UCTD), overlap syndromes, lupus e...