Marijuana and the Endocannabinoids 1 Synthesis and Release 2 Inactivation 2 Receptors 2 Distribution and Function 2 Cannabinoids and Ocular Tissues 3 CannabinoidsdRetinal Anatomy 3 LocalizationdCannabinoid Receptors 4 LocalizationdSynthesizing and Catabolic Enzymes 4 CannabinoidsdRetinal Physiology 4 Effects on Transmitter Release 4 Effects on Ganglion Cells 5 Effects on Amacrine Cells 5 Effect...

BACKGROUND The use of cannabis, or marijuana, for medicinal purposes is deeply rooted though history, dating back to ancient times. It once held a prominent position in the history of medicine, recommended by many eminent physicians for numerous diseases, particularly headache and migraine. Through the decades, this plant has taken a fascinating journey from a legal and frequently prescribed st...

We provide a systematic review and meta-analysis on the efficacy, tolerability, and safety of cannabinoids in palliative medicine. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, PubMed, Scopus, and http://clinicaltrials.gov, and a selection of cancer journals were searched up until 15th of March 2017. Of the 108 screened studies, nine studies with a total of 15...

Oral cannabinoids for spasticity in multiple sclerosis: will attitude continue to limit use? See page 1517 Spasticity is a distressing and disabling symptom that many people with multiple sclerosis face daily because there is inadequate treatment. As one part of an upper motor-neuron syndrome, spasticity manifests as muscle stiffness, spasms, and pain. It also contributes to limited mobility an...

BACKGROUND Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects. Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion. METHODS Matrigel-coated and uncoated Boyden chambers were used to quantify invasiveness and migration, respe...

The endocannabinoid system is involved in various physiological pathways the human body. A large number of endogenous cannabinoids have been acknowledged, and cannabinoid receptor type 1 (CB-1) 2 (CB-2) categorized.

Here is the latest summary of research abstracts. A reminder that the 2005 Symposium on the Cannabinoids to be held June 24th 27th, 2005 at the Hilton Clearwater Beach Resort in Clearwater, Florida USA; registration details are available at http://CannabinoidSociety.org/. In addition a workshop entitled “Cannabinoids: developing clinically useful analgesics” has been announced at the Internatio...

Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work ...

QUESTION One of my breastfeeding patients is using marijuana to combat chronic pain. Is it safe for her to breastfeed? ANSWER Lactating mothers should refrain from consuming cannabinoids. Advising mothers to discontinue breastfeeding if they cannot stop using cannabinoids must incorporate the known risks of formula feeding. Cannabinoid exposure through milk has not been shown to increase neon...