Cannabinoids form a singular group of plant-derived compounds, endogenous lipids and synthetic derivatives with multiple therapeutic effects exerted by targeting different elements the endocannabinoid system. One their applications is preservation neuronal integrity attenuating neurotoxic events that kill neurons in neurodegenerative disorders. In this review, we will address potential cannabin...

Chronic D-tetrahydrocannabinol (D-THC) administration produces tolerance to cannabinoid effects, but alterations in signal transduction that mediate these changes are not yet known. The present study uses in vitro autoradiography of agoniststimulated [S]GTPgS binding to localize cannabinoid receptor-activated G-proteins after chronic D-THC treatment. Cannabinoid (WIN 55212-2)-stimulated [S]GTPg...

Natural cannabinoids have been used for centuries for their psychotropic properties, but their possible therapeutic implications in analgesia have been recently documented. The present review intended to make an analysis of the neuroanatomy and physiology of the cannabinoid system (receptors, functions, agents acting on these receptors) and of its implications in neuropathic pain. There were al...

The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-depende...

Cannabinoid receptors have been localized in the central and peripheral nervous system as well as on cells of the immune system, but recent studies on animal tissue gave evidence for the presence of cannabinoid receptors in different types of tissues. Their presence was supposed also in myofascial tissue, suggesting that the endocannabinoid system may help resolve myofascial trigger points and ...

cloned and characterized from mammalian tissues, the seven transmembrane G protein-coupled cannabinoid receptors type 1 (CB1 receptor), [5] and type 2 (CB2 receptor) [6]. Whereas the CB1 receptor expression is abundant in the central nervous system, the CB2 receptor is almost exclusively expressed in the immune system. The CB1 receptor is also expressed in peripheral nerve terminals and various...

Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level). As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more positively when they experience positive events, these two aspects of happiness are interrelated. According to a recent...

Medical benefits of cannabis and related compounds is widely known. Discovery psychotropic plant cannabinoid ?9-tetrahydrocannabinol have urged researchers to study more about the system therapeutics in field neurology medicine. Where activation receptor type 1 (CB1R) yielded unwanted serious side effects, discovery 2 (CB2R) its ligands gave a new hope. Till now there limited success this becau...