DESCRIPTION A 35-year-old man suffered a self-inflicted work injury from a circular saw on the dorsum of the thumb on his nondominant hand, sustaining a total transection of his extensor pollicus longus (EPL) and a concomitant dorsal capsule injury.

Teat injuries are common in dairy cattle and, compared to other frequently occurring diseases, these injuries often result in premature culling of affected cows. Teat injuries can be divided in 2 categories: external or internal injuries. The external injuries include all types of laceration. The internal injuries include disease of the teat cistern and papillary duct. During this session, the ...

Extracellular nucleotides regulate critical liver functions via the activation of specific transmembrane receptors. The hepatic levels of extracellular nucleotides, and therefore the related downstream signaling cascades, are modulated by cell-surface enzymes called ectonucleotidases, including nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39), NTPDase2/CD39L1, and ecto-5'-nucleotida...

The determination of lacunar-canalicular permeability is essential for understanding local fluid flow in bone, which may indicate how bone senses changes in the mechanical environment to regulate mechano-adaptation. The estimates of lacunar-canalicular permeability found in the literature vary by up to eight orders of magnitude, and age-related permeability changes have not been measured in non...

UNLABELLED Estradiol 17ß-D-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways play complementary roles in E17G cholestasis. Since non-conjugated estradiol is capable of activating these pathways ...

Hepatocytes and cholangiocytes release ATP into bile, where it is rapidly degraded into adenosine and P(i). In rat, biliary P(i) concentration (0.01 mM) is approximately 100-fold and 200-fold lower than in hepatocytes and plasma, respectively, indicating active reabsorption of biliary P(i). We aimed to functionally characterize canalicular P(i) reabsorption in rat liver and to identify the invo...

Lacrimal scintigraphy (LS) was performed in 860 lacrimal drainage systems (LDS) in 188 patients with bilateral epiphora and 226 patients with unilateral epiphora. A very high incidence of canalicular obstruction was found in these patients, the incidence being higher in the group with unilateral epiphora. It is suggested that a canalicular block is a commoner cause of obstructive epiphora than ...

Human bile salt export pump (BSEP) mutations underlie progressive familial intrahepatic cholestasis type 2 (PFIC2). In the PFIC2 animal model, Bsep(-/-) mice, biliary secretion of bile salts (BS) is decreased, but that of phospholipids (PL) and cholesterol (CH) is increased. Under physiological conditions, the biliary secretion of PL and CH is positively related ("coupled") to that of BS. We ai...

Traumatic laceration of the tibialis anterior tendon complicating a closed tibial shaft fracture is a rare injury pattern. Only 3 such cases have been reported to date in the English literature and all were missed on initial examination. A case of a 17-year-old motorcyclist with an acute laceration of the tibialis anterior tendon resulting from a closed oblique tibial shaft fracture is presente...

A x6-year-old girl was admitted to Bristol Eye Hospital in May, I968. For the previous 3 days there had been a painful swelling of the right eyelids associated with a vesicular eruption of the margin of the right upper lid, and shortly before admission some vesicles appeared at the angle of the mouth. The girl's boy-friend had noticed a "cold sore" on his lip i I days previously. The patient ha...