BACKGROUND The influence of artificial sweeteners on metabolic diseases is controversial. Artificially sweetened beverages have been associated with an increased risk of type 2 diabetes (T2D) but biases and reverse causation have been suspected to have influenced the observed association. In addition, it has been suggested that investigation into the relationship between the frequency and durat...

Evidence linking sugar-sweetened beverage (SSB) consumption to weight gain and other negative health outcomes has prompted many individuals to resort to artificial, non-nutritive sweetener (NNS) substitutes as a means of reducing SSB intake. However, there is a great deal of controversy regarding the biological consequences of NNS use, with accumulating evidence suggesting that NNS consumption ...

S. rebaudiana produces steviol glycosides including stevioside and rebaudioside A that are valuable as low calorie sweeteners. The objective of this study was to investigate the effects of salicylic acid elicitation and sampling times on the improvment of stevioside and rebaudioside A production and KA13H, UGT74G1 and UGT76G1 genes expression. The results showed that the addition of different c...

Artificial sweeteners are food additives whose use has been controlled by European Parliament guidelines. The method described in this application note, shows how LC-MS/MS can be used to simultaneously detect and confirm the presence of several artificial sweeteners. The method is both quicker than conventional non LC-MS/MS methods and more sensitive. This has meant that these compounds can be ...

I . The effect of saccharin and cyclamate on growth of young rats fed on a poor rice diet or a balanced diet was investigated. 2. Saccharin and cyclamate retarded the growth of rats on the multi-deficient diet but not of those on the well-balanced diet during an 8-week feeding period. 3. The sweeteners did not produce any macroscopic or microscopic changes in the liver, kidneys, intestines, spl...

Animal models suggest that sucrose activates taste afferents differently than non-caloric sweeteners. Little information exists how artificial sweeteners engage central taste pathways in the human brain. We assessed sucrose and sucralose taste pleasantness across a concentration gradient in 12 healthy control women and applied 10% sucrose and matched sucralose during functional magnet resonance...