At the 1988 Seoul Olympic Games, four double somersaults dismounts with one twist and four double somersault dismounts with two twists were filmed using two 16 mm cameras during the men’s horizontal bar competition. Contributions to tilt angles reached at the mid-twist position, determined using computer simulations based on modifications of the data obtained from film, were used as measures of...

In Drosophila, a coordinate interplay between the Rel transcription factor Dorsal and the basic Helix-Loop-Helix transcription factor Twist initiates mesoderm formation by activating the zygotic expression of mesoderm-determining genes. Here, we show that TBP-associated-factors (TAF(II)s) within the basal transcription factor TFIID mediate transcriptional activation by Dorsal and Twist. Dorsal ...

Metastasis is a multistep process during which cancer cells disseminate from the site of primary tumors and establish secondary tumors in distant organs. In a search for key regulators of metastasis in a murine breast tumor model, we have found that the transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in metastasis. Suppression of Twist expressi...

To understand the role of twist during mammalian development, we generated twist-null mice. twist-null embryos died at embryonic day 11.5. Their most prominent phenotype was a failure of the cranial neural folds to fuse. Mutant embryos also had defects in head mesenchyme, somites, and limb buds. Chimera analysis suggested that head mesenchyme was required for cranial neural tube closure and tha...

We present a first study of gluonic twist-four corrections to the deep inelastic structure function F2 at small x and small Q 2. The calculations are based upon the double logarithmic approximation of the coupled twist-four evolution equations of the gluonic twist-four operators that are expected to be dominant at small x. We first review the analytical results which are presently available and...

Understanding how basic helix-loop-helix (bHLH) transcription factors cause changes in gene expression is important for revealing how transcriptional cascades function in development. Several bHLH transcription factors such as MyoD and NeuroD have been shown to play important roles in promoting myogenesis and neurogenesis, respectively (for a review, see Massari and Murre, 2000). These transcri...

The target mass corrections are calculated for all structure functions of neutral and charged current deep inelastic scattering in lowest order in the coupling constant. Representations of the correction to the twist–2 and twist–3 contributions are derived both in Mellin-n and x-space. The impact of the target mass corrections on the general relations between the twist–2 and twist–3 parts of th...

Cis-regulatory modules (CRMs) function by binding sequence specific transcription factors, but the relationship between in vivo physical binding and the regulatory capacity of factor-bound DNA elements remains uncertain. We investigate this relationship for the well-studied Twist factor in Drosophila melanogaster embryos by analyzing genome-wide factor occupancy and testing the functional signi...

OBJECTIVE Left ventricular (LV) rotation and twist play an important role in LV contraction and relaxation. Left bundle branch block (LBBB) deteriorates both diastolic and systolic functions. We evaluated the LV twist in patients with LBBB and preserved ejection fraction (EF) (>50%) to determine twist as a potential marker for subtle myocardial dysfunction. METHODS This observational cross-se...

BACKGROUND miRNAs are involved in osteosarcoma (OS) chemoresistance, and TWIST reportedly enhances cisplatin-induced OS cell apoptosis by inhibiting multiple signaling pathways. In this study, we profiled miRNAs differentially expressed in chemoresistant OS, with a focus to identify miRNAs that regulate TWIST expression and OS chemoresistance. METHODS OS patients who showed <90% tumor necrosi...