Stanniocalcin 1 (STC1) and calcitonin gene-related peptide (CGRP) are involved in bone formation/remodeling. Here we investigate the effects of STC1 on functional heterodimer complex CALCRL/RAMP1, expression and activity during osteoblastogenesis. STC1 did not modify CALCRL and ramp1 gene expression during osteoblastogenesis when compared to controls. However, plasma membrane spatial distributi...

To assess the role of protein kinase C and cAMP on the calcitonin-induced alteration of phosphate accumulation by renal tubular cells, the effects of phorbol esters, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and DBcAMP on the phosphate accumulation in LLC-PK1 cells were investigated. Calcitonin stimulated phosphate accumulation with a concomitant increase in cAMP production. Phorbol ...

The calcium-sensing receptor (CaSR)-specific allosteric modulator cinacalcet has revolutionized the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. However, its application is limited to patients with end-stage renal disease because of hypocalcemic side effects presumably caused by CaSR-mediated calcitonin secretion from thyroid parafollicular C-cells. These ...

Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). This study investigated the effects of IMD in paraventricular nucleus (PVN) on renal sympathetic nerve activity and mean arterial pressure and its downstream mechanism in hyper...

Calcitonin gene related peptide immunoreactivity was investigated in the rat lung. Immunoreactive material was observed in nerve fibres surrounding bronchi, bronchioli, and blood vessels, and also in neuroendocrine cells and neuroepithelial bodies. In addition, the peptide was identified by immunoelectron microscopy in dense cored vesicles of granulated cells of the neuroepithelial bodies. Thes...

introduction: in order to develop a radiolabeled calcitonin (ct) derivative for receptor imaging studies, ct was successively labeled with 67ga-gallium chloride. methods: the best results of the conjugation were obtained by the addition of 0.5 ml of a ct nasal pharmaceutical solution (1100 iu) to a glass tube pre-coated with dtpa-dianhydride (0.01 mg) at 25°c with continuous mild stirring for 3...

High calcitonin levels noted on a totally healthy 49-year-old man participating in a calcitonin control project led to a presumptive diagnosis of medullary carcinoma. Complete thyroid studies augmented by selective catheterization and quantitative calcitonin studies confirmed the clinical impression of medullary carcinoma. Surgery was recommended and a total thyroidectomy was performed. On gros...

The comprehensive literature data and our findings about calcium-regulating hormones participant in the glucose metabolism is analyzed. It is showed calcitonin hyperglycemic effect and its mechanisms, established contra-insulin effect of calcitonin to insulin under the pre-receptor, cell level and liver. It is ascertained the impairment of glucose metabolism under calcitonin hyperglycemia, insu...

Osteoarthritis (OA) is a progressive disorder characterized by destruction of articular cartilage and subchondral bone, and is associated with synovial changes [1,2]. This degenerative condition affects aging men and women [3]. The two most affected locations for pain and physical disability in adults are hip and knee [4]. Owing to its important prevalence worldwide, OA represents a huge burden...

Introduction Calcitonin-gene-related peptide (CGRP) is a 37-amino acid neuropeptide which was first identified in 1982 as a product of the calcitonin gene derived by alternative splicing [ 11. This original peptide is now referred to as a-CGRP; a second gene, unrelated to calcitonin, produces P-CGRP [2]. These two forms are closely related in both rat and man (Figure l ) , and are widely distri...