background: this study aims to investigate the concentrations of lead, cadmium, and arsenic in the human milk, and to assess the effect of jujube fruit consumption by lactating mothers in reducing the concentration of these heavy metals in their milk.materials and methods: this randomized controlled trial was conducted in 2014 among forty postpartum mothers in isfahan,the second largest and pol...

As part of an environmental health study of northwest Florida, we conducted an initial screening level assessment of contaminants in blue crabs (Callinectes sapidus) and oysters (Crassostrea virginica) collected in bays and bayous in the Pensacola, FL area. Tissue samples were analyzed for mercury, arsenic, cadmium, chromium, copper, lead, nickel, selenium, tin, zinc, 17 dioxin/furan compounds,...

Abstract Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management metastatic disease remains unresolved. Brain metastasis is a late complication frequently observed among cancer, whose poor prognosis calls for novel more effective therapies. Here, we report that active hypoxia inducible factor...

OBJECTIVE Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster of metabolic disorders in which adipose is one of the first affected tissues. The role of hypoxia and hypoxia-inducible factor 1 (HIF1) in the development of high-fat diet (HFD)-induced obesity and insulin resistance was investigated using animal models. RESEARCH DESIGN AND METHODS Mice with adipocyte...

Hypoxia-inducible factor promotes erythropoiesis through coordinated cell type-specific hypoxia responses. GATA1 is essential to normal erythropoiesis and plays a crucial role in erythroid differentiation. In this study, we show that hypoxia-induced GATA1 expression is mediated by HIF1 in erythroid cells. Under hypoxic conditions, significantly increased GATA1 mRNA and protein levels were detec...

BACKGROUND Arctic populations are exposed to mercury, lead and cadmium through their traditional diet. Studies have however shown that cadmium exposure is most often attributable to tobacco smoking. The aim of this study is to examine the trends in mercury, lead and cadmium exposure between 1992 and 2004 in the Inuit population of Nunavik (Northern Québec, Canada) using the data obtained from t...

Fascioliasis has medical and veterinary importance in Iran. Human Fascioliasis had been limited to just ectopic cases or sporadic reports before 1988. In this year an outbreak of human fascioliasis was reported from Gilan province and peak of this epidemy was seen in spring 1989. Considering 100000 population of Bandar-e-Anzali total infected cases was estimated between 9800 and up to 20000 ...

INTRODUCTION Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction. To verify this hypothesis, we investigated whether body oxygen consumption (VO2), that primarily depends on mitochondrial respiration, is depressed in patients with biguanide intoxication. METHODS Multicentre retrospective analysis of data ...

Heavy metals have the properties of biological accumulation, toxicity and environmental stability, hence consumption of drinking water containing heavy metals can jeopardize human health. One of these heavy metals is cadmium that its long-term exposure causes kidney diseases, osteoporosis, cancer and cardiovascular disease. In this cross-sectional study which was conducted in Minab, 100 samples...