نتایج جستجو برای: butyrylcholinesterase inhibitors
تعداد نتایج: 189613 فیلتر نتایج به سال:
The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to clinical trial. However, the supply of the native human proteins is either limited (e.g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinesterase) or nonexisting (synaptic acetylcholinesterase). Here we identify a unique form...
To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD. A series of new anthrarobin acyl derivatives (2-8) were synthesized by the reaction of anthrarobin (1) and acetic anhydride/acyl chlorides. The product were characterized by 1H NMR and E...
Nervous system disorders, such as Alzheimer’s disease (AD) and schizophrenia, are believed to be caused in part by the loss of choline acetyltransferase (ChAT) expression and activity, which is responsible for the formation of the neurotransmitter acetylcholine (ACh). ACh is biosynthesized by ChAT by acetylation of choline, which is in turn biosynthesized from l-serine. ACh is involved in many ...
A screening aimed at obtaining a cholinesterase inhibitor of microbial origin was carried out using Pseudomonas butyrylcholinesterase. A mycelium-extract of a fungus strain, belonging to the genus Penicillium, was found to produce such an enzyme inhibitor. The inhibitor was purified and crystallized as colorless leaflets. From physical and chemical studies, the inhibitor was identified as being...
In this work, a series of anti-tyrosinase and anti-butyrylcholinesterase coumarin derivatives 4a–f 5a–f were synthesized starting from 4-hydroxycoumarin. The condensation 2-(arylimin)-4-hydroxycoumarins 3a–f with dimethylformamide dimethyl acetal (DMF-DMA), used as key reaction, afforded the precursors 4a–f, whose acid treatment led to formation 5a–f. These prepared heterocycles characterized b...
Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) and capecitabine and the pyrethroid insecticides. Because of the role of CEs in the metabolism of many exogenous and endogenous ester-containing compounds, a number of studies have examined the inhibition of this class ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید