Interspecies embryo transfer is a possible approach that can be used to conserve endangered species. It could provide a useful technique to preserve the Iranian and wild Bactrian camels, both of which are threatened with extinction. In the present study, one Bactrian camel was superovulated using decreasing doses of FSH (60, 40, 30, 30, 20, 20 mg, b.i.d.; Folltropin-V; Bioniche, London, ON, Can...

Kisspeptin is the peptide product of KISS-1 gene and endogenous agonist for Kiss1 receptor. It well known that kisspeptin acts centrally, stimulates secretion gonadoliberin (GnRH). Further, also interacts with other neuropeptides such as neurokinin B dynorphin to regulate GnRH pulse generation plays a key role in sexual behavior. This study aimed evaluate effect on male rats' motivation its dep...

The current review summarizes progress in the field of in vitro and in vivo production of South American Camelid embryos. Both methods require ovarian superstimulation (with FSH and eCG) to obtain multiple ovulations (in vivo embryo production) or to induce follicle growth for oocyte collection (in vitro embryo production). Moreover, superstimulation entails prior administration of hormones tha...

BACKGROUND Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extremely rare. CASE REPORT This is the first report of a case with AFP-negative, differentiated hepatocellular carcinoma metastasis to the abdominal wall ...

A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stability of 17 disparate peptide drugs (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, [Arg(8)]-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, hi...

38 Lactating dairy cows (n=1,538) were enrolled in a randomized complete block 39 design study to evaluate protocols to synchronize estrus and ovulation. Within each 40 herd (n=8), cows were divided into three calving groups: EARLY, MID and LATE 41 based on days in milk (DIM) at mating start date (MSD). EARLY calving cows 42 (n=1,244) were  42 DIM at MSD, MID calving cows (n=179) were 21 to 41...

We review the crucial role of the two neurotransmitters norepinephrine (NE) and GABA in eliciting GnRH pulse. NE acts via an alpha l-receptor mechanism and also GABA acts at the alpha-subtype of the GABA receptor. The function of NE appears to be induction of phasic activation of GnRH neurons and GABA inhibits GnRH neurons tonically until they are all ready for phasic activation. By an unknown ...

PURPOSE We assessed pathological outcomes as well as the feasibility of combined docetaxel and androgen deprivation therapy in men with prostate cancer before undergoing prostatectomy. MATERIALS AND METHODS In this phase II multicenter study of newly diagnosed patients with untreated clinically localized prostate cancer and high risk features, all patients received androgen deprivation therap...

BACKGROUND The effect of recombinant human LH (r-hLH; lutropin alfa) in women undergoing controlled ovarian stimulation with recombinant human FSH (r-hFSH) prior to IVF was investigated. METHODS After down-regulation with the GnRH agonist, buserelin, 114 normo-ovulatory women (aged 18-37 years) received r-hFSH alone until the lead follicle reached a diameter of 14 mm. Patients were then rando...