Cdc7-Dbf4 is a conserved, two-subunit kinase required for initiating eukaryotic DNA replication. Recent studies have shown that Cdc7-Dbf4 also regulates the mitotic exit network (MEN) and monopolar homolog orientation in meiosis I (Matos, J., Lipp, J. J., Bogdanova, A., Guillot, S., Okaz, E., Junqueira, M., Shevchenko, A., and Zachariae, W. (2008) Cell 135, 662-678 and Miller, C. T., Gabrielse,...

TWO CASE STUDIES STEFAN M UNCH University of Karlsruhe (TH), IPR, Kaiserstr. 12, 76128 Karlsruhe, Germany and MICHAEL SASSIN, SIEGFRIED BOCIONEK Siemens AG, ZFE ST SN 6, Otto-Hahn-Ring 6, 81739 Munich, Germany ABSTRACT Programming by Demonstration (PbD) is a new programming method in which new functionalities are coded by simply showing them to a PbD system. The prospects of possibly successfu...

BACKGROUND Pediatric Bipolar Disorder (PBD) is a debilitating condition associated with impairment in many domains. Social functioning is one of the disorder's most notable areas of impairment and this deficit may be in part due to difficulties recognizing affect in others. METHODS In the present study, medication naïve youth with PBD were compared to age-matched healthy controls on their abi...

Tibeto-Burman populations of India provide an insight into the peopling of India and aid in understanding their genetic relationship with populations of East, South and Southeast Asia. The study investigates the genetic status of one such Tibeto-Burman group, Adi of Arunachal Pradesh based on 15 autosomal microsatellite markers. Further the study examines, based on 9 common microsatellite loci,...

BACKGROUND AND STUDY AIMS Selective biliary cannulation is unsuccessful in 5 % to 10 % of patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for malignant distal biliary obstruction (MDBO). Percutaneous biliary drainage (PBD) has been the gold standard, but endoscopic ultrasound guided rendezvous (EUSr) have been increasingly used for biliary decompression in this patient...

BACKGROUND The U.S. Centers for Disease Control and Prevention collected health, housing, and environmental data in a single integrated national survey for the first time in the United States in 1999-2004. OBJECTIVES We aimed to determine how floor dust lead (PbD) loadings and other housing factors influence childhood blood lead (PbB) levels and lead poisoning. METHODS We analyzed data from...

In this paper, I present the results of an examination of the relational morphology in 76 Tibeto-Burman languages, primarily from the Bodic section of Tibeto-Burman. I will discuss a set of etymons used to express relational functions and show how the meanings of the reflexes of these etymons have evolved. I will then go on to discuss overall patterns of syncretism of relational markers in thes...

In this paper, we are interested inminimizing the sum of block sizes in a pairwise balanced design, where there are some constraints on the size of one block or the size of the largest block. For every positive integers n,m, wherem ≤ n, letS (n,m) be the smallest integer s for which there exists a PBD on n points whose largest block has sizem and the sum of its block sizes is equal to s. Also, ...

Let K be a set of positive integers. A pairwise balanced design (PBD) of index unity B(K,l;v) is a pair (X/~) where X is a v-set (of points) and B is a collection of subsets of X (called blocks) with sizes from K such that every pair of distinct points of X is contained in exactly one block of~. A necessary condition for the existence of a PBD B({4,8},I;v) is v-0 or l(mod 4). It is shown that t...

M. H. Skolnick et at. (1) obtained specimens by multiple fine-needle aspiration from the breasts of women with and without a family history of breast cancer. They assessed the prevalence of certain cytologic changes in these groups of women, which they labeled proliferative breast disease (PBD). Skolnick et al.'s use of this term is unfortunate because PBD is a well-recognized histologic diagno...