نتایج جستجو برای: burkitt lymphoma
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BACKGROUND Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore underto...
We would like to offer two critical comments on the PNAS paper by Doose et al. entitled “MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells” (1). Doose et al.’s (1) paper claims that MINCR is a MYC-induced long noncoding (lnc) RNA. The authors base this claim upon three pieces of evidence, correlation of expression in P493-6 cells, in hT-RPE-M...
INTRODUCTION Burkitt-like lymphoma (BLL) is a provisional category of B-cell lymphoma which is morphologically intermediate between Burkitt lymphoma (BL) and large B-cell lymphoma (LBCL). The clinical significance of this morphology is controversial. PATIENTS AND METHODS We examined 41 cases of pediatric B-cell lymphoma by immunohistochemistry for proteins associated with proto-oncogenes c-my...
Primary breast lymphoma (PBL) of the breast is a rare type of localized non-Hodgkin lymphoma, which is usually of the B-cell. The majority of breast lymphoma present as a unilateral painless breast masses in an older woman, average age at diagnosis 55-60. A less common but distinctive presentation is a young woman of childbearing age who presents during or immediately after pregnancy. We presen...
The stomach is the most frequent site of extranodal malignant lymphomas. The most common gastric lymphomas are mucosa-associated lymphoid tissue (MALT) and diffuse large B cell lymphomas. Burkitt’s lymphoma is a highly aggressive non-Hodgkin lymphoma. In the sporadic form, patients usually present with abdominal disease, with involvement of the distal ileum, cecum and mesentery. Although the tr...
OBJECTIVES Recently described, aggressive B-cell lymphomas with genetic abnormalities involving MYC and BCL2 have been shown to have a poor prognosis when treated with regimens for diffuse large B-cell lymphomas. Similar data on cases with concurrent MYC and BCL6 translocation are still scant. Moreover, little is known regarding the morphologic and immunophenotypic characteristics of these case...
Burkitt lymphoma (BL) exhibits a characteristic immunophenotype that is positive for pan-B-cell antigens and CD10 and expresses clonal surface immunoglobulins (SIgs). We evaluated 35 BLs and identified atypical immunophenotypes in 4 including SIg light chain negativity in 4, negativity for B-cell antigens in 2, lack of CD10 in 1, and CD4 expression in 1. All 4 cases showed morphologic features ...
Burkitt in Uganda in 1958. Through his diligent observations, research, and the subsequent contributions of other pioneers in the field, Burkitt’s lymphoma is now considered by some to be a model tumor secondary to its impact on the general understanding and treatment of lymphomas. 1 The study of Burkitt’s lymphoma has also been groundbreaking in the understanding of viruses such as Epstein Bar...
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