Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and...

Mucous membrane pemphigoid (MMP) is a rare nosological entity. MMP consists of a clinical phenotype in which several autoimmune subepidermal bullous diseases are classified. It occurs predominantly in the mucous membranes and usually results in scarring. Esophageal involvement in MMP is rare and is generally seen in patients in whom lesions are widespread. The most common alterations are multip...

Background Nottingham Clinical Trials Unit is co-ordinating two RCTs in rare skin diseases: one recruited people with pyoderma gangrenosum (STOP GAP), the other people with bullous pemphigoid (BLISTER). Sites were initially identified via the UK Dermatology Clinical Trials Network (http://www.ukdctn.org) without using formal site selection criteria. Many sites were naive, having not recruited t...

Pemphigus is a severe, potentially fatal bullous skin disease, caused by desmoglein autoantibody production and immune-mediated regulation of T-cells subsets. Conventional therapy including systemic corticosteroids with or without other immunosupressants causes numerous adverse effects and becomes inefficient in refractory patients. In this work, the authors showed a modern view on the pathogen...

BACKGROUND Bullous pemphigoid has developed in association with different types of malignant diseases, including a few cases of B-cell lymphoproliferative disorders. However, the paraneoplastic significance of this association is still controversial. OBSERVATIONS We describe a 39-year-old patient who presented with a bullous eruption and generalized lymphadenopathy. The results of histologic,...

ophionyssus natricis is a purely blood sucking parasite of snakes and of worldwide distribution. infected snakes often exhibit lethargy, pruritus, crusting dermatitis,and behavioral changes. ophionyssus natricis can also attack humans, causing popular vesiculo-bullous eruption of the skin. a 29 years old man working in zoo,sari, mazandaran, iran, presented itchy papullar eruption of the skin. h...

INTRODUCTION Isoradiotopic responses were first described in 2004 by Shurman et al as the development of unrelated dermatoses within previously irradiated skin. Several case reports describe development of auto-antibodyemediated diseases in the radiation treatment field including bullous pemphigoid and pemphigus vulgaris. To our knowledge, only 5 cases of postradiotherapy LP have been reported ...

Bullous pemphigoid is a subepidermal autoimmune blistering disease associated with autoantibodies to the hemidesmosomal bullous pemphigoid antigens 180 and 230. Most sera from bullous pemphigoid patients recognize epitopes within the N-terminal NC16A portion of the bullous pemphigoid 180 ectodomain. Using cryosections of human skin, patients' sera were shown to generate dermal-epidermal separat...

Multiple observations point to involvement of lipid membrane domains, known as lipid rafts, in the pathology of human disorders. The putative role of lipid rafts in hereditary and acquired skin blistering diseases is discussed in this review. Stable adhesion of the epidermis to the underlying basement membrane is secured by hemidesmosomes, specialized multiprotein complexes in basal keratinocyt...

BACKGROUND Various antigen-specific immunoassays are available for the serological diagnosis of autoimmune bullous diseases. However, a spectrum of different tissue-based and monovalent antigen-specific assays is required to establish the diagnosis. BIOCHIP mosaics consisting of different antigen substrates allow polyvalent immunofluorescence (IF) tests and provide antibody profiles in a single...