Myasthenia gravis (MG) is a rare chronic autoimmune neuromuscular disorder, which causes debilitating and potentially life-threatening exacerbations of muscle weakness. The objective this study was to develop novel United States (US) budget impact analysis framework assess innovative MG treatments. A targeted literature review conducted identify previous economic evaluations MG. Clinical expert...

We study multi unit auctions in presence of budget constraints. This situation is very common in real world but has not received proper attention in theoretical literature. We will study the impact of budget on the different aspects of multi unit auctions. These results try to define a frame work in which multi unit auctions with budget constraints are working and problem we are facing in desig...

BACKGROUND Long-acting insulin analogues for type 1 diabetes (T1D) treatment have been available on the Brazilian market since 2002. However, the population cannot access the analogues through the public health system. OBJECTIVE To estimate the incremental budget impact of long-acting insulin analogues coverage for T1D patients in the Brazilian public health system compared to NPH insulin. ...

OBJECTIVES This study aims to assess the value for money and budget impact of offering hemodialysis (HD) as a first-line treatment, or the HD-first policy, and the peritoneal dialysis (PD) first policy compared to a supportive care option in patients with end-stage renal disease (ESRD) in Indonesia. METHODS A Markov model-based economic evaluation was performed using local and international d...

This paper presents a change impact analysis approach created as part of a model-driven development (MDD) environment. Its purpose is to give project stakeholders the ability to better assess the impact that requirement changes will impose on project schedule and budget. Using MDD techniques and visualization tools we were able to automate requirement change impact analysis. Therefore, the foll...