Çok-etmenli Sistemler’in (ÇES) geliştirilmesi amacıyla literatürde çeşitli ÇES yazılım geliştirme metodolojileri yer almaktadır. Ancak bu metodolojilerin ÇES’leri geliştirmede kullanılmasına ve etmen yazılımı geliştiricilerin faydalanabileceği deneyimlerin aktarılmasına yönelik çalışma pek azdır. Ulusal boyutta ise bu tip bir çalışmanın hemen hemen hiç yapılmadığı gözlenmektedir. Bu bildiride s...

A novel type of deprotonative functionalization of aromatics was accomplished with a phosphazene base (t-Bu-P4 base). For various nitrogen heteroaromatics and benzene derivatives, deprotonative 1,2-additions proceeded with the t-Bu-P4 base and ZnI(2) as an additive in the presence of carbonyl compounds. The t-Bu-P4 base has both extremely strong Brønsted basicity and less nucleophilicity due to...

A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neurological examination and EEG were performed prior to and soon after completio...

This paper presents an algorithm for interconnect layout optimization with bu er insertion. Given a source and n sinks of a signal net, with given positions and a required arrival time associated with each sink, the algorithm nds a bu ered Steiner tree so that the required arrival time (or timing slack) at the source is maximized. In the algorithm, Steiner routing tree construction and bu er in...

This study investigated the effect of backchannel utterances (BU) as a strategy to facilitate idea generation when a listener was copresent with a speaker who was engaged in idea generation. Twenty-four female undergraduate students participated in the main experiment, which used a think-aloud method. Independent variables were frequency of BU from listeners, and the task category of idea gener...

BACKGROUND Land use and land cover (LULC) change is one anthropogenic disturbance linked to infectious disease emergence. Current research has focused largely on wildlife and vector-borne zoonotic diseases, neglecting to investigate landscape disturbance and environmental bacterial infections. One example is Buruli ulcer (BU) disease, a necrotizing skin disease caused by the environmental patho...

During natural vision, eye movements are dynamically controlled by the combinations of goal-related top-down (TD) and stimulus-related bottom-up (BU) neural signals that map onto objects or locations of interest in the visual world. In primates, both BU and TD signals converge in many areas of the brain, including the intermediate layers of the superior colliculus (SCi), a midbrain structure th...

Different regimens are used to achieve immune tolerance in patients with severe haemophilia A and inhibitory allo-antibodies against factor VIII (FVIII). In this study, results of 26 years of low dose immune tolerance induction are evaluated. We evaluated 21 patients, who were treated with regular infusions of low dose FVIII (25-50 IU kg(-1) every other day or three times a week) to obtain immu...

BACKGROUND Buruli ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Previous studies have shown that wounds of BU patients are colonized with M. ulcerans and several other microorganisms, including Staphylococcus aureus, which may interfere with wound healing. The present study was therefore aimed at investigating the diversity and topography of S. aureus colonizing BU ...

Buruli ulcer (BU), a neglected tropical disease of the skin, caused by Mycobacterium ulcerans, occurs most frequently in children in West Africa. Risk factors for BU include proximity to slow flowing water, poor wound care and not wearing protective clothing. Man-made alterations of the environment have been suggested to lead to increased BU incidence. M. ulcerans DNA has been detected in the e...