There is evidence that a link exists between the upper and lower respiratory tracts. During the last fifty years many clinical observations has lead to a new pathogenic view of rhinosinusitis and asthma defined as Sinobronchial Syndrome. The inflammatory process in the nose and bronchi explains some of the complex interactions among different clinical diseases, such as rhinosinusitis, asthma, b...

Background Epidemiological studies in South Africa show increasing prevalence rates of asthma and allergic sensitisation in both urban and rural Black African communities, and narrowing of the urban-rural gradient. There is a paucity of current data on bronchial hyperresponsiveness (BHR) in urban Black African children, associations between asthma and BHR and the relationship between BHR, aller...

Acute bronchitis is a common disorder usually assumed to be caused by a viral infection with no beneficial effect resulting from antibiotic treatment. We examined whether acute bronchitis in a healthy individual should be regarded as an isolated event or a predictor of chronic lung disorders that has not yet clearly manifested itself clinically—that is, as bronchial hyperresponsiveness, asthma,...

Usually, hyperresponsiveness to inhaled methacholine is considered closely associated with a diagnosis of bronchial asthma. Recently, it has been clearly pointed out that bronchial hyperreactivity (BHR) is not a constant feature of asthma and that this condition is not always related to airways inflammation. In the present study we evaluated 42 Patients (21 positive and 21 negative for bronchia...

Exercise-induced bronchoconstriction is caused by heat loss and water loss through respiration during exercise, leading to mediator release in the airways and to increased parasympathetic nervous activity in the airways, thereby causing constriction of bronchial smooth muscle and increased bronchial secretions as well as vasodilation in the bronchial vessels. Development of asthma and bronchial...

Activation of naive T cells requires at least two signals. In addition to the well characterized interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen-presenting cell, T cell activation also requires costimulation by a second set of signals. The best characterized costimulatory receptor is CD28, which binds to a family of B7 ligands expressed on antigen-present...

BACKGROUND Chronic cough is characterized by sensory neuropathy. Vitamin B-12 (cobalamin) deficiency (Cbl-D) causes central and peripheral nervous system damage and has been implicated in sensory neuropathy and autonomic nervous system dysfunction. OBJECTIVE We evaluated whether Cbl-D has a role in chronic, unexplained cough. DESIGN Laryngeal threshold (histamine concentration that provokes...

BACKGROUND A decline in host resistance due to an alteration in diet--primarily of salt--was recently put forward as a possible explanation for rising rates of asthma. METHODS A case-control study was conducted in participants in a prevalence survey which included 187 children with asthma (defined by prior diagnosis and/or a decline in forced expiratory volume in one second (FEV1) of > or = 1...