Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruction by bronchospasm and bronchial wall thickening due to smooth muscle hypertrophy. A rise in cytosolic free Ca2+ concentration ([Ca2+]cyt) may serve as a shared signal transduction element that causes bronchial constriction and bronchial wall thickening in asthma. In this study, we examined whethe...

OBJECTIVES To determine whether bronchial colonisations/infections with periodontopathogenic bacteria are associated with elevated inflammatory markers such as MMPs, interleukins and Tumor necrosis factor alpha in the bronchial fluid. METHODS Periodontal status was assessed in consecutive outpatients planned for elective bronchoscopies, and PCR for periodontopathogenic bacteria was performed ...

Amikacin was given to 14 noninfected men as three consecutive intramuscular injections (7.5 mg/kg) at 12-h intervals. Serum and bronchial secretion specimens were obtained at various times during flexible fiberoptic bronchoscopy after the final dose. Serum and bronchial secretion concentrations obtained between 1.5 and 2.0 h after the final dose ranged from 17 to 40 mug/ml and 2.3 to 8.4 mug/ml...

We define asthma as a syndrome consisting of paroxysmal, recurrent and reversible partial obstruction of the lower bronchial tree resulting in the development of acute obstructive emphysema. Variability is a striking clinical feature of asthma both from patient to patient and in the same patient from day to day. The factors which produce bronchial obstruction in asthma are mucosal edema and con...

BACKGROUND Nearly all asthmatic subjects show bronchial hyperresponsiveness, in that the provocative concentration of histamine reducing forced expiratory volume in one second (FEV1) by 20% (PC20FEV1) is < or = 8 mg/ml histamine, and have underlying chronic inflammation of the bronchial wall mediated by T cells. The possible cause and effect relationship between these phenomena remains an enigm...

unilateral pulmonary artery agenesis (upaa) is a rare congenital anomaly during the 4 th  week of gestational age. it is defined as an absence of pulmonary parenchyma and its supporting artery. a 9-year-old girl was admitted to our hospital because of chronic cough. chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. chest radiography (cxr) revealed a...

A double-blind crossover study of the effects of real and placebo acupuncture on bronchial reactivity to histamine was carried out on 16 patients with moderately severe asthma. Treatment with real or placebo acupuncture failed to modulate the bronchial hyperreactivity to histamine. These results suggest that a single treatment with acupuncture is unlikely to provide improvement in the managemen...

Expandable metallic stents seemed to be a good method in tuberculous bronchial stenosis that does not respond to medical therapy. But there was no long-term follow-up study after stents insertion in tuberculous bronchial stenosis. We report a case of obstruction after successful Gianturco metallic stents insertion due to tuberculous bronchial stenosis.

Sweeney, Michele, Sharon S. McDaniel, Oleksandr Platoshyn, Shen Zhang, Ying Yu, Bethany R. Lapp, Ying Zhao, Patricia A. Thistlethwaite, and Jason X.-J. Yuan. Role of capacitative Ca2 entry in bronchial contraction and remodeling. J Appl Physiol 92: 1594–1602, 2002; 10.1152/japplphysiol.00722.2001.—Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruct...