We report a case of typhoid fever in a traveler returning to Spain from Guatemala that was caused by Salmonella enterica serovar Typhi which produced an extended-spectrum β-lactamase (ESBL). This finding demonstrates the presence of ESBL-producing S. enterica ser. Typhi strains in the Americas. Enhanced surveillance is necessary to prevent further spread.

Introduction and objective: Klebsiella is an opportunistic pathogen that is an important cause of nosocomial infections. The prevalence of extended spectrum beta-lactamases (ESBLs)-producing strains and their resistance to betalactam antibiotics has had a daily increase. Because of the importance of these enzymes in Klebsiella pneumonia, this study was carried out to investigate it’s prevalence...

OBJECTIVES We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia. METHODS We searched the PubMed database using the terms 'bacteremia or bloodstream' and 'ESBL or extended-spectrum beta-lactamase'. Included studies contained numbers of and mort...

We investigated the gastrointestinal colonization rate and antibiotic resistance patterns of Extended-Spectrum Beta-Lactamase (ESBL)- producing Escherichia coli and Klebsiella pneumoniae in hospitalized patients admitted at Ethiopia's largest tertiary hospital. Fecal samples/swabs from 267 patients were cultured on chrome agar. ESBL. Bacterial species identification, verification of ESBL produc...

After contact precautions were discontinued, we determined nosocomial transmission of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli by screening hospital patients who shared rooms with ESBL-producing E. coli-infected or -colonized patients. Transmission rates were 2.6% and 8.8% at an acute-care and a geriatric/rehabilitation hospital, respectively. Prolonged contact was associ...

Background Group 3a/b cephalosporins are currently being used in the treatment of UTI and urosepsis. However, Extended Spectrum Beta-Lactamase (ESBL) mediated resistance has been increasingly reported among uropathogens from HIV patients. We sought to determine the incidence of ESBL genesblaCTX-M, blaTEM and blaSHV among E. coli isolates from HIV (with increased exposure to cephalosporins) and ...

Sir, We read with great interest the letter by Nix and Matthias 1 regarding pharmacokinetic considerations relating to tigecycline use in urinary tract infections (UTIs). We agree with the authors that tige-cycline should not be used for UTIs when other therapies including aminoglycosides, carbapenems and colistin are options; however, in rare situations, tigecycline may be considered. In a rec...

We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A hi...

OBJECTIVE We hypothesized that admission screening for extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) reduces the incidence of hospital-acquired ESBL-E clinical isolates. DESIGN Retrospective cohort study. SETTING 12 hospitals (6 screening and 6 non-screening) in Toronto, Canada. PATIENTS All adult inpatients with an ESBL-E positive culture collected from 2005-2009. ...

background: ampc and esbls as mediated-plasmid extended spectrum β-lactabases are the main factors of resistance to extended-spectrum cephalosporins in enterobacteriacea especially e. coli and will follow treatment failure, high costs of treatment in human and economic losses in the poultry industry. objectives: the purpose of this study was to screen and study the faecal e. coli isolates produ...