I propose to give a review of the effect of drugs on lipid metabolism which will be extensive rather than intensive. Several excellent reviews are available that discuss the drugs which are most effective for lowering plasma lipid levels in the six main types of human hyperlipoproteinaemia (Lees & Wilson, 1971 ; British Medical Journal, I 972 ; Levy, Fredrickson, Shulman, Bilheimer, Breslow, St...

Non-Gaussian outcomes are often modeled using members of the so-called exponential family. The Poisson model for count data falls within this tradition. The family in general, and the Poisson model in particular, are at the same time convenient since mathematically elegant, but in need of extension since often somewhat restrictive. Two of the main rationales for existing extensions are (1) the ...

A novel computational method is proposed in this work for use in discovering reaction mechanisms and solving the kinetics of transition metal-catalyzed reactions. The method does not rely on either chemical intuition or assumed a priori mechanisms, and it works in a fully automated fashion. Its core is a procedure, recently developed by one of the authors, that combines accelerated direct dynam...

We consider a class of semi-parametric dynamic models with strong white noise errors. This processes includes the standard Vector Autoregressive (VAR) model, nonfundamental structural VAR, mixed causal-noncausal models, as well nonlinear such (multivariate) ARCH-M model. For estimation in this class, we propose Generalized Covariance (GCov) estimator, which is obtained by minimizing residual-ba...

AIM To describe changes in leisure time and occupational physical activity status in an urban Mediterranean population-based cohort, and to evaluate sociodemographic, health-related and lifestyle correlates of such changes. METHODS Data for this study come from the Cornellè Health Interview Survey Follow-Up Study, a prospective cohort study of a representative sample (n = 2500) of the populat...

The paper considers the problem of determining the number of matched sets in 1 : M matched case-control studies with a categorical exposure having k + 1 categories, k > or = 1. The basic interest lies in constructing a test statistic to test whether the exposure is associated with the disease. Estimates of the k odds ratios for 1 : M matched case-control studies with dichotomous exposure and fo...

BACKGROUND Power for assessing interactions during data analysis is often poor in epidemiologic studies. This is because epidemiologic studies are frequently powered primarily to assess main effects only. In light of this, some investigators raise the Type I error rate, thereby increasing power, when testing interactions. However, this is a poor analysis strategy if the study is chronically und...

 This paper considers the problem of estimating the population mean Ybar of the study variate Y using information on different parameters such as population mean $(bar{X})$, coefficient of variation $(C_x)$, kurtosis  $beta_{2(x)}$, standard deviation $(S_x)$ of the auxiliary variate x and on the correlation coefficient, $rho$, between the study variate $Y$ and the auxiliary variate $...