Introduction: Primary breast lymphoma (PBL) is a rare form of extranodal lymphoma. The most common pathology diffuse large B cell and patients are diagnosed at stages 1 2. therapeutic options available so far include surgery, radiotherapy, chemotherapy Case Presentation: patient was 54-year old woman with localized primary B-cell (DLBCL). underwent 6 courses an R-CHOP regimen followed by radiot...

BACKGROUND Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of heart disease is uncertain. We performed a meta-analysis to investigate the link between radiotherapy and long-term cardiovascular morbidity and mortality in patients with breast cancer. METHODS AND RESULTS We performed a l...

BACKGROUND The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. METHODS Two hundred fo...

OBJECTIVE To conduct a systematic review to gather the available evidence on the optimum timing of the radiotherapy in relation to autologous breast reconstruction. MATERIAL AND METHODS The data was extracted from scientific databases, and a manual follow-up of references. The studies were selected which included at least 20 patients with any method of autologous breast reconstruction who wer...

BACKGROUND An important issue in palliative radiation oncology is the whether whole-brain radiotherapy should be added to radiosurgery when treating a limited number of brain metastases. To optimize personalized treatment of cancer patients with brain metastases, the value of whole-brain radiotherapy should be described separately for each tumor entity. This study investigated the role of whole...

BACKGROUND Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent dose during surgery. However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial. METHODS This study was done at the European Institute of Oncolo...

Although protracted cognitive impairment has been reported to occur after radiotherapy even when such therapy is not directed to brain areas, the mechanism remains unclear. This study investigated whether breast cancer patients exposed to local radiotherapy showed lower cognitive function mediated by higher plasma interleukin (IL)-6 levels than those unexposed. We performed the Wechsler Memory ...

PURPOSE Postoperative radiotherapy for breast cancer has a number of associated complications. This study examined whether supervised moderate-intensity exercise could mitigate the complications that occur during radiotherapy. PATIENTS AND METHODS Forty women were randomized before radiotherapy after various operations for breast cancer. Seventeen patients who were assigned to the exercise gr...

TO THE EDITOR: The increasing complexity and cost of conducting randomized trials have stimulated interest in using observational data sets to evaluate cancer treatments. Determining the causal effect of treatments from observational data is, however, challenging because more aggressive treatments are selectively prescribed for patients with adverse disease characteristics or favorable comorbid...

background: quantification of radiation-induced apoptosis in peripheral blood lymphocytes (pbls) has been proposed as a possible screening test for cancer-prone individuals and also for the prediction of normal tissue responses after radiotherapy. materials and methods: the neutral version of the comet assay (single-cell gel electrophoresis) was used 24, 48, 72 hours after irradiation with 8 gy...