objective: breast cancer is the most common cancer among women in the world. early diagnosis of this cancer is a key element for its treatment. one of the approaches for diagnosis of breast cancer is detection of its tumour-associated markers. hence, her2 has been the main focus of the researches in the field. materials and methods: for diagnosis of her2 overexpression, monoclonal antibodies (m...

The origin of cell lines is critical in defining cell type-specific biological functions. Several reports suggested that the MDA-MB-435 cell line, a cell line extensively used for studying breast cancer biology, has a gene expression pattern most compatible with melanocyte origin. However, we demonstrate that MDA-MB-435 cells express breast-specific or epithelial-specific markers. Also, MDA-MB-...

background: heme oxygenase-1 (ho-1) is a cytoprotective and antiapoptotic enzyme, which has been involved in maintaining cellular homeostasis, and plays an important protective role by modulating oxidative injury. up-regulation of (ho-1) has contributed to tumorogenicity of some cancers. in this study we investigated the expression pattern of the ho-1, in five different human-derived cancer cel...

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, bi...

PURPOSE Quantification of the heterogeneity of tumor cell populations is of interest for many diagnostic and therapeutic applications, including determining the cancerous stage of tumors. We attempted to differentiate human breast cancer cell lines from different pathologic stages and compare that with a normal human breast tissue cell line by characterizing the impedance properties of each cel...

Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. Caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. The...

background: breast cancer is one of the main life-threatening diseases which a woman may face during her life. several lifestyle factors such as weight gain, obesity, fat intake and decreased level of physical activity are associated with breast cancer risk.   in vitro and vivo studies showed that, linoleic acid (la) is one of the main fatty acids composition of nigella sativa. the objective wa...

Sodium butyrate-induced differentiation of breast cancer cell lines was used to identify protein tyrosine phosphatases (PTPs) involved in differ entiation and growth inhibition of breast cancer cells Of 42 PTPs ana lyzed, 31 were expressed in the ZR75-1 breast cancer cell line. Expression offour PTPs (DEP-1, SAP, P'FP'y,and PAC) was regulated in ZR75-1 cells undergoing differentiation. Expressi...