Heart failure with preserved ejection fraction (HFPEF), a clinical syndrome where heart failure (HF) exists in the presence of normal or near-normal left ventricular ejection fraction (LVEF), accounts for up to half of all HF patients. However, in contrast to heart failure with reduced ejection fraction (HFREF), where therapeutic advances have significantly improved outcomes over the last two d...

Dynamic modeling and simulation of fixed bed adsorption process was carried out by explaining the behavior of breakthrough curve parameter. Adsorption of sulfur compound, present in road fuel, has posed a great challenge. A model of fixed bed adsorption of benzothiophene from fuel was formulated with non-ideal plug flow behavior and considered velocity variation along a column. The model was so...

In July 2012, Congress passed the Advancing Breakthrough Therapies for Patients Act as part of the Food and Drug Administration Safety and Innovation Act (FDASIA). Section 902 of FDASIA provides for designation of a drug as a breakthrough therapy Bif the drug is intended alone or in combination with one or more other drugs, to treat serious or life-threatening diseases or conditions and prelimi...

Breakthrough seizures are often encountered in patients with well-controlled epilepsy for no obvious reason. We report a case of a breakthrough seizure after temporal lobectomy secondary to topical administration of essential oils. We recommend inquiring about the use of essential oils in patients with well-controlled epilepsy who experience breakthrough seizures.

We thank Dr. Blennow and Dr. Kalin for their comments (1) relating to our recent paper (2). They argue that some of the cases included in our study as breakthrough fungal infections occurring while patients were taking posaconazole prophylaxis are not cases of “invasive” fungal infections (IFIs). To clarify, we agree that case 4 (culture-proven oral candidiasis), case 7 (culture-proven urinary ...

Whole glove testing for a metalworking fluid (MWF) in the field was performed for the first time. Green latex gloves used in a machine shop were exposed for 20 min to MWF. The permeated amount (1.0 +/- 0.5 microg/cm(2)) was higher than the threshold (0.25 microg/cm(2)) for the ASTM F739-99a closed-loop normalized breakthrough time.

Breakthrough cancer pain is defined as transient pain exacerbation in patients with stable and controlled basal pain. Although variable, the prevalence of breakthrough cancer pain is high (33%-95%). According to the American Pain Foundation, breakthrough pain is observed in 50%-90% of all hospitalized cancer patients, in 89% of all patients admitted to homes for the elderly and terminal-patient...

Certain events settle themselves in the collective memory of humankind where they keep functioning for decades as points of reference for future generations. The announcement of the successful cloning of Dolly was such an event. Every one of us will remember this thought-provoking occasion or will, at least, be confronted with the extended media coverage of this breakthrough in medical science....

Background. Good postoperative analgesic management improves maternal satisfaction and care of the neonate. Postoperative pain management is a challenge in Mulago Hospital, yet ketamine is accessible and has proven benefit. We determined ketamine's postoperative analgesic effects. Materials and Methods. We did an RCT among consenting parturients that were randomized to receive either intravenou...

Hepatitis B virus (HBV) infection after liver transplantation (LT) may lead to severe and rapidly progressive graft failure. Antiviral treatment may be of benefit in selected patients with recurrent hepatitis B post-LT. The aim of this prospective open-label study is to determine the safety and efficacy of lamivudine in 33 liver transplant recipients with active HBV infection. The median time f...