Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Sequence variations in the coding region of the prion gene (PRNP) have been associated with acquired transmissible spongiform encephalopathy (TSE) susceptibility in mammals; however, this is not the case in cattle. It has be...

(2001) Communicable disease outbreaks involving more than one country: systems approach to evaluating the response. two main groups—one familiar " sporadic " disease (that is, Jakob's disease) and another affecting a younger age group, as in Creutzfeldt's case. The differing features between the groups may reflect infection with a differently conformed prion with a particular pattern of spread ...

Bovine spongiform encephalopathy (BSE) was first described in the United Kingdom (UK) in November 1986. After the introduction of an active surveillance system, most countries in Europe have reported BSE cases in the cattle population. This indicates that the use of active surveillance in addition to passive surveillance is important to assess the true BSE status in a country. Scrapie, a transm...

page 1 of 9 Importance Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease, caused by a prion, that mainly affects cattle. Other ruminant species, cats and humans are occasionally affected; this disease is called feline spongiform encephalopathy (FSE) in cats, and variant Creutzfeldt–Jakob disease (vCJD) in humans. BSE is a relatively new disease that was first reported ...

Bovine spongiform encephalopathy (BSE), a member of the prion diseases, is a fatal neurodegenerative disorder suspected to be caused by a malfunction of prion protein (PrP). Although BSE prions have been reported to be transmitted to a wide range of animal species, dogs and hamsters are known to be BSE-resistant animals. Analysis of canine and hamster PrP could elucidate the molecular mechanism...

Iatrogenic transmission by blood transfusion has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bovine spongiform encephalopathy (BSE), and natural sheep scrapie, demonstrating that blood in these prion diseases is infectious. However, the possible effect of the transfusion, derived from differences in the inoculum (blood) and the route of infectio...

BACKGROUND Sheep with prion protein (PrP) gene polymorphisms QQ171 and RQ171 were shown to be susceptible to the prion causing L-type bovine spongiform encephalopathy (L-BSE), although RQ171 sheep specifically propagated a distinctive prion molecular phenotype in their brains, characterized by a high molecular mass protease-resistant PrP fragment (HMM PrPres), distinct from L-BSE in QQ171 sheep...

BACKGROUND Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease of cattle. The bovine prion gene (PRNP) contains regions of both high and low linkage disequilibrium (LD) that appear to be conserved across Bos taurus populations. The region of high LD, which spans the promoter and part of intron 2, contains polymorphic loci that have been associated with classical BSE st...

The global increase in seafood demand has resulted significant growth aquaculture production a wide range of aquatic species. Consequently, this led to an industry-wide need find sustainable feed ingredients that would meet the nutritional requirements used aquafeeds. associated dependency on plant by-products as major alternatives brought concerns through carbon footprint, deforestation and ar...

ABSTRACT: Transmissible spongiform encephalopathies are neurodegenerative diseases that affect several mammalian species. Bovine spongiform encephalopathy (BSE) is among the mentioned diseases in cattle caused by abnormally fold prion proteins. Polymorphisms of the prion protein gene (PRNP) have been shown to be major determinations for the susceptibility to transmitted perion diseases in human...