The main detectors used for clinical dosimetry are ionisation chambers and semiconductors. Thermoluminescent (TL) dosimeters are also of interest because of their following advantages: i) wide useful dose range, ii) small physical size, iii) no need for high voltage or cables, i.e. stand alone character, and iv) tissue equivalence (LiF) for most radiation types. TL detectors can particularly be...

PURPOSE The aim of this study is evaluation of the effect of diameter of (10)B nanoparticles and various neutron capture cross-section libraries on macroscopic dose enhancement in boron neutron capture therapy (BNCT). MATERIAL AND METHODS MCNPX Monte Carlo code was used for simulation of a (252)Cf source, a soft tissue phantom and a tumor containing (10)B nanoparticles. Using (252)Cf as a neu...

The Legnaro National Laboratories (LNL) of the Italian National Institute of Nuclear Physics (INFN) are developing a neutron source within the SPES-BNCT project. An accelerator-based, high-flux thermal neutron beam facility is planned for the experimental treatment of skin melanoma. Neutrons are produced via the Be(p,n) reaction by bombarding a 1 mm thick beryllium target with 5 MeV protons gen...

Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the D-D or D-T fusion reactions. In this new neut...

Success of boron neutron capture therapy (BNCT) is dependent on cellular and molecular targeting of sufficient amounts of boron-10 to sustain a lethal B (n, ) Li capture reaction. The purpose of the present study was to determine the efficacy of boronated epidermal growth factor (EGF) either alone or in combination with boronophenylalanine (BPA) as delivery agents for an epidermal growth factor...

Pseudoprogression has been recognized and widely accepted in the treatment of malignant gliomas, as transient increases in the volume of the enhanced area just after chemoradiotherapy, especially using temozolomide. We experienced a similar phenomenon in the treatment of malignant gliomas and meningiomas using boron neutron capture therapy (BNCT), a cell-selective form of particle radiation. He...

Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compou...

Clinical trials of boron neutron capture therapy (BNCT) for recurrent breast cancers are considered at Japan Research Reactor No. 4 (JRR-4). In this study, the irradiation technique for a total mastectomy patient with recurrent cancer was optimized by dosimetric calculations using JAEA computational dosimetry system (JCDS). The evaluation was performed using an en face technique and a tangents ...

Background: The amount of average dose enhancement in tumor loaded with 10B may vary due to various factors in boron neutron capture therapy.Objective: This study aims to evaluate dose enhancement in tumor loaded with 10B under influence of various factors and investigate the dependence of this dose enhancement on neutron spectra changes.Material and Methods: In this simulation stud...

Abstract Boron neutron capture therapy (BNCT) is a promising cancer treatment that selectively destroys tumor cells using beam. However, accurately and fast measuring the spatial distribution of flux critical to ensuring effective treatment. To address this challenge, Micromegas detectors are applied for first time measure beam in BNCT. Due high flux, large area, multiple components BNCT beam, ...