Adenoviruses show promising potential as vectors for cancer vaccines, however, their high immunogenicity can be problematic when it comes to homologous prime-boost strategies. In the studies presented here we show that heterologous prime-boost vaccinations involving ovalbumin (OVA)-antigen-coated microparticles as a prime, and adenovirus encoding OVA (AdOVA) as a boost, were equally as effectiv...

1 This work is supported by Philips Research, Briarcliff Manor, NY, through Colorado Power Electronics Center Abstract – In converters for power-factor-correction (PFC), universal-input capability (ability to operate from any AC line voltage, world-wide) comes with a heavy price in terms of component stresses and losses, size of components, and restrictions on the output DC voltage. A new two-s...

The increase in levels of blood nicotine that occurs from smoking a single cigarette, sometimes referred to as a "nicotine boost," is an individualized measure of how much nicotine has been extracted from smoking a cigarette. This study investigated the demographic, smoking status, and psychological predictors of nicotine boost in a sample of 190 treatment-seeking smokers. Boost was assessed by...

This paper presents an interleaved boost converter with coupled inductors for photovoltaic (PV) energy conversion. The proposed soft-switching boost converter uses an interleaved method to increase its power density and coupled-inductor technology to extend its step-up voltage ratio. To reduce switching losses of active switches, the proposed interleaved boost converter incorporates a synchrono...

flee abroad, while none from outside Italy can penetrate the system. After various reforms and several rounds of decentralisation followed by recentralisation, the whole process may have to be reconstructed from scratch. " A recent bill passed last year intends to [...] promote meritocracy, " Calef adds, " but it is not very clear whether it can succeed. " This is a particularly sensitive area,...

Due to its simplicity and versatility, k-means remains popular since it was proposed three decades ago. Since then, continuous efforts have been taken to enhance its performance. Unfortunately, a good trade-off between quality and efficiency is hardly reached. In this paper, a novel k-means variant is presented. Different from most of k-means variants, the clustering procedure is explicitly dri...

Ensemble methods such as AdaBoost are popular machine learning methods that create highly accurate classifier by combining the predictions from several classifiers. We present a parametrized method of AdaBoost that we call Top-k Parametrized Boost. We evaluate our and other popular ensemble methods from a classification perspective on several real datasets. Our empirical study shows that our me...

the usage of turbochargers in diesel engines has led to the downsizing of the motors as well as usage of the waste gates in turbochargers. any dimensional reduction in turbochargers and appurtenant leads to an enhancement on the performance of internal combustion engines and in environmental problems in terms of aerodynamic, thermodynamic and mechanical specifications for both engines and turbo...

For decades detailed molecular biology about malaria has been accrued: but, throughout this time, the most effective measures in regions where the disease is endemic have continued to rely on the chemical and physical methods of insecticides and bednets, with drugs available to people travelling to these regions. So the latest study to test a new malaria vaccine developed by GlaxoSmithKline (GS...