OBJECTIVE Bone marrow fibrosis is the second most common complication that causes morbidity and mortality inpatients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate theassociation between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with MPNs. MATERIAL AND METHODS In total, 149 patients with MPNs were retrospecti...

We recently reported that a DNA plasmid coding p62-SQSTM1 acts as an effective anti tumor vaccine against both transplantable mouse tumors and canine spontaneous mammary neoplasms. Here we report the unexpected finding that intramuscular delivery of p62 DNA exerts a powerful anti-osteoporotic activity in a mouse model of inflammatory bone loss (i.e, ovariectomy) by combining bone-sparing and os...

T hedifferential diagnosis for an adult patient presenting with an aggressive-appearing bone lesion includes metastatic disease, multiple myeloma, lymphoma, chondrosarcoma, osteosarcoma, nonneoplastic conditions such as infection, and metabolic bone diseases such as Paget disease of bone. An accurate diagnosis is critical as it will guide the treatment and goals of care. The true prevalence of ...

Bone marrow is a complex organ containing undifferentiated cells from which the various constituents of blood originate. Under the control of hormones, cytokines and growth factors, normal marrow is susceptible to proliferation or suppression secondary to multiple influences, to include infection, medications, radiation, toxins, neoplasms, and nutritional deficiencies, among others. While histo...

Amongst all the controversies regarding the classification of osteogenic neoplasms, the giantcell tumour, under one name or another, has always remained a distinct entity. In fact, the subject of contention in this connection has been the nomenclature of this distinct variety of tumour formation in the bone which, though locally destructive, practically never presents any of the general feature...

Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion. This subset can radiologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis. Meanwhile histological diagnosis can be extremely challenging too, as the pathological features often resemble that of aneurysmal bone cysts. We presen...

Recent determinations of serum phosphatase activity in patients with cancer (1, 2, 3) suggest that values obtained in cases with widespread osteoplastic metastases are, in general, significantly higher than those found in association with osteolytic metastases. In the series reported by Gutman, Tyson and Gutman (1), for example, the serum phosphatase activity exceeded 10 Bodansky units per 100 ...

INTRODUCTION The orbit may be directly involved by neoplasms or other destructive processes arising from the orbital contents, the osseous framework or, indirectly, as extensions of extraorbital tumors from the sinuses or cranial vault. In most osseous neoplasms of the orbit, and in tumors with extension into the orbit from surrounding areas, resection of part or all of the orbital walls will b...

Summary Myeloproliferative neoplasms (MPN) are clonal hematological conditions characterized by excessive production of one or more cell lines in the bone marrow. The blood cells produced often hyperactive their functions, which could lead to complications disorder‘s clinical course. We aimed define role granulocytic CD11b/CD18 expression for thrombotic risk MPN patients. investigated 110 patie...

Using a currently employed linear accelerator, our intent was to inactivate peroxidase/catalase in tumor tissue by the application of hydrogen peroxide, which is degraded to produce oxygen, thus re-oxygenizing the tumor tissue. In this way, we can convert radioresistant tumors into radiosensitive ones. On the basis of this strategy, we previously developed a new enzyme-targeting radiosensitizat...