Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared ...

In active RA, bone resorption is increased and bone formation is normal or reduced in comparison to healthy controls. This uncoupling of bone formation and resorption with a negative remodelling balance leads to generalized bone loss. The pathogenesis of this altered bone metabolism is multifactorial, involving non-disease-specific factors (such as age, female sex and postmenopausal status) and...

The prevalence of chronic kidney disease (CKD) is increasing, and CKD patients are at risk for severe adverse outcomes such as progressive loss of kidney function, cardiovascular (CV) disease, and premature death [1]. CKD-Mineral and Bone Disorder (CKD-MBD) is the clinical syndrome that develops as a systemic disorder of bone and mineral metabolism due to CKD, which is manifested by abnormaliti...

Osteosarcoma (OS) is the most common malignant bone tumor found in children. Currently, researchers have focused on protein and gene levels, while the associated metabolic variations have been poorly understood. In this study, we used a gas chromatography mass spectrometry approach and profiled small-molecule metabolites in serum and urine of 24 OS patients, 19 benign bone tumor patients, and 3...

Osteoporosis is a major health problem in both elderly women and men. Epidemiological evidence has shown an association between tea consumption and the prevention of age-related bone loss in elderly women and men. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures. This review ...

Osteoporosis is a serious social issue nowadays. Both the high morbidity and its common complication osteoporotic fracture load a heavy burden on the whole society. The adipose tissue is the biggest endocrinology organ that has a different function on the bone. The adipocytes are differentiated from the same cell lineage with osteoblast, and they can secrete multiple adipokines with various fun...

Osteoporosis and atherosclerosis are chronic degenerative diseases which have been considered to be independent and whose common characteristic is increasing incidence with age. At present, growing evidence indicates the existence of a correlation between cardiovascular disease and osteoporosis, irrespective of age. The morbidity and mortality of osteoporosis is mainly related to the occurrence...

Osteoporosis (OP) is the most widely spread metabolic osteopathy in the Western world, and is defined as a generalised state of the skeletal structure, characterised by a low bone mass and microarchitectural alterations, with an increase in bone fragility and risk of fracture (1). OP is now considered as an evolutive disorder affecting both the mineral and organic components leading to a progre...

INTRODUCTION Heavy ion particle radiation is interesting to know biological effects of space radiation. There are problems to assess the magnitude of radiation-induced damages in the astronauts. It is known that the bone minerals reduce after flight, the cause might be estimated by mainly microgravity. However, there are few studies on effects of heavy ion particle irradiation to bone metabolis...

Primary Hypercalciuria (PH) is very frequently accompanied by some degrees of bone demineralization. The most frequent clinical condition in which this association has been studied is calcium nephrolithiasis. In these patients bone density has been reported to be very frequently low and increased susceptibility to fragility fractures has been described. One of the most important aspects is the ...