BACKGROUND Without exploitation of possibly immunogenic and carcinogenic bone morphogenetic protein, we developed simple but clinically feasible artificial bone graft using osteoconductive hyaluronate (HA) hydrogels and bioactive MegaGen synthetic bone (MGSB). METHODS HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin (GEL). Th...

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...

A novel gelatin prepared by enzymatic catalysis (type-E bone gelatin) was developed in our group. In this study, the high crosslinking activity of type-E with microbial transglutaminase (MTGase) found and further used for gelatinization properties minced pork. The results showed that contents lysine glutamine were higher than traditional acid (type-A alkali (type-B methods, which are as action ...

Nanovesicles In article 2300315 by Jiacan Su, Meng Li, Jie Gao, and co-workers, GelMA-NVs, defined as gelatin methacryloyl hydrogels loaded with exosome-mimicking mesenchymal stem cell-derived nanovesicles (MSC-NVs), exhibit sustained release of MSC-NVs which could increase chondrocyte human bone marrow MSC differentiation, proliferation, migration induce M2 macrophage polarization.

Phospholipids are category of nutrients that essential for growth and health maintenance. They commonly supplied from animal-derived foods. However, plant-derived phospholipids like soy lecithin seems also to be potential alternative because they well received by different population who have concerns about The purpose the current investigation is formulate gelatin-based matrix bearing as a mod...

BACKGROUND Interstitial collagen plays a crucial structural role in arteries. Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant. METHODS AND RESULTS Because Mmp14-/- mice die by 3 weeks of age, this study used lethally irradiated low-density lipoprotein recep...

OBJECTIVE To evaluate the hemostatic efficacy and handling of gelatin-thrombin matrix in abdominal myomectomy. DESIGN Prospective and randomized trial. SETTING University teaching hospital. PATIENT(S) Women (n = 50) with uterine fibroids with a uterine size equivalent to > or =16 weeks gestation. INTERVENTION(S) Gelatin-thrombin matrix (FloSeal Matrix; Baxter Healthcare Corp., Fremont, ...

In this study, we developed an injectable gelatin-transglutaminase (TGase) gel for cell delivery. The procedure provides a minimally invasive approach to deliver cells into tissue in a manner that improves localization. The results indicate gelatin-TGase to be noncytotoxic and to have adhesive properties that help localize and prevent the scattering of the cells after delivery. The in situ cros...

There is an association between diabetes and impaired bone healing. The purpose of this study was to determine whether sericin had a positive effect on regeneration with streptozotocin-induced in rat model. Sprague Dawley rats (n = 21) were assigned one three groups. A critical-sized defect created the calvaria. In group (S group, n 7), filled sericin–gelatin combination, whereas gelatin (G onl...

We have developed a technique for fabricating microfluidic devices from gelatin using a natural crosslinking process. Gelatin, crosslinked with the naturally occurring enzyme transglutaminase is molded to produce microchannels suitable for adherent cell culture and analysis. The autofluorescence of the material was shown to be minimal and within the range of typical background, ensuring utility...