OBJECTIVES To determine whether disruption of the p53 gene leads to preservation of trabecular bone volume (BV) after limb immobilisation. MATERIALS AND METHODS Tibias of immobilised hind limbs of p53 gene knockout (p53(-/-)) and wild-type (p53(+/+)) mice were compared. Right knee joints of 8 week old mice were immobilised in full extension for 7 days. Trabecular structure and bone formation ...

Background: There are multiple methods for acceleration of bone healing. Bone marrow has been shown to contain osteoprogenitor cells. Objective: To determine the effect of percutaneous bone marrow injection on bone healing. Methods: 15 mature, 2-kg-weighing white New Zealand rabbits from both sexes were randomized into 3 groups: Group I: Only osteotomy of right radius was performed and a 5 mm b...

Methotrexate is the conventional disease-modifying anti-rheumatic drug (DMARD) which considered of choice in treatment rheumatoid arthritis, but its prolonged use without monitoring leads to a number complications involving different body systems. The toxic effects long-term methotrexate (MTX) therapy mainly involve liver, skin, gastrointestinal tract (GIT) and bone marrow. In marrow, it causes...

Acquired amegakaryocytic thrombocytopenic purpura (AATP) is a disorder of hematopoiesis characterized by severe thrombocytopenia due to a selective reduction or total absence of megakaryocytes in an otherwise normalappearing bone marrow. Although the development of autoantibodies directed against cells in the megakaryocyte progenitor cell pool has been implicated in the pathogenesis of this dis...

objective(s):to study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. materials and methods:forty new zealand rabbits were randomly divided into five groups with eight rabbits in each group. for each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. to t...

Bone loss in type 1 diabetes is accompanied by increased marrow fat, which could directly reduce osteoblast activity or result from altered bone marrow mesenchymal cell lineage selection (adipocyte vs. osteoblast). CCAAT/enhancer binding protein beta (C/EBPβ) is an important regulator of both adipocyte and osteoblast differentiation. C/EBPβ-null mice have delayed bone formation and defective li...

background: bone marrow transplant (bmt) recipients are prone to bacterial, viral and fungal infections. bacterial infec­tion is considered as one of the common and serious complications in bone marrow transplant recipients. the aim of this study was to determine the rate of bacterial infections in bone marrow transplant recipients. methods: fifty-two blood and 25 catheter samples were obtained...

croenvironment, Wnt3A acts to promote osteoblast differentiation and suppress osteoclastogenesis. This results in inhibition of myeloma bone disease and consequent indirect suppression of tumor growth. These studies advance our knowledge of myeloma bone disease, and raise questions regarding the balance of agonists and antagonists of the Wnt signaling pathway in myeloma, and the function of Wnt...

Oxidative DNA damage in bone marrow cells is the main side effect of chemotherapy drugs including cyclophosphamide (CTX). However, not all antioxidants are effective in inhibiting oxidative DNA damage. In this study, we report the beneficial effect of carnosine (β-alanyl-l-histidine), a special antioxidant with acrolein-sequestering ability, on CTX-induced bone marrow cell suppression. Our resu...