PURPOSE Prostate tumor cells frequently show the features of osteoblasts, which are differentiated from bone marrow mesenchymal stem cells. We examined human prostate cancer cell lines and clinical prostate cancer specimens for additional bone marrow mesenchymal stem cell properties. EXPERIMENTAL DESIGN Prostate cancer cell lines were induced for osteoblastogenic and adipogenic differentiatio...

BACKGROUND The bone morphogenetic proteins (BMPs) belong to a unique group of proteins that includes the growth factor TGF-β. BMPs play important roles in cell differentiation, cell proliferation, and inhibition of cell growth. They also participate in the maturation of several cell types, depending on the microenvironment and interactions with other regulatory factors. Depending on their conce...

Introduction: Mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. These include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. In this research we wer...

BACKGROUND The standard treatment for decompensated liver cirrhosis is liver transplantation. However, it has several limitations. Recent animal studies suggest that bone marrow stem cell transplantation can lead to regression of liver fibrosis. The objective of this study was to determine the safety and feasibility of autologous bone marrow-mesenchymal stem cell transplantation in patients wit...

We determined a transcriptional profile specific for clonal stromal mesenchymal stem cells from adult and fetal hematopoietic sites. To identify mesenchymal stem cell-like stromal cell lines, we evaluated the adipocytic, osteoblastic, chondrocytic, and vascular smooth muscle differentiation potential and also the hematopoietic supportive (stromal) capacity of six mouse stromal cell lines from a...

Chronic Obstructive Pulmonary Disease (COPD) is a common disease associated with high morbidity and mortality rates. It characterized by airway parenchymal inflammation leading to narrowing, decreased lung recoil, eventual airflow limitation. Despite the advance in therapeutic approaches, no curative clinical treatment for COPD exists. We present case of 74-year-old gentleman diagnosed who unde...

The bone marrow microenvironment is home to mesenchymal and haematopoietic stem cells and their respective progeny. Mesenchymal stem cells are multipotent and have the capacity to differentiate into a number of cell types, namely osteoblasts, adipocytes and chondrocytes. These cells and cells of the haematopoietic lineage maintain close interactions within the marrow cavity and are responsible ...

Subcutaneous adipose tissue has recently been attracting attention as a new cell source for regenerative medicine, replacing bone marrow. Among fibroblast-like cells, termed adipose stromal cells, stromalvascular cells, and preadipocytes, cells with potency to differentiate into not only adipocytes and blood vessels but also various lineages are present [1], and they are termed adipose-derived ...

Perichondrium in fetal limb is composed of undifferentiated mesenchymal cells. However, the multipotency of cells in this region and the role of perichondrium in bone marrow formation are not well understood. In this report, we purified and characterized perichondrial cells using a monoclonal antibody against activated leukocyte cell adhesion molecule (ALCAM) and investigated the role of perich...

This investigation aimed to examine the protective function of vitamin E on rat bone marrow mesenchymal stem cells (MSCs) treated with cadmium chloride. Rat bone marrow MSCs were extracted using flashing-out and cultured in DMEM containing 10% FBS and 100 U/ml Pen/Strep. At the end of the third passage, cells were divided into 4 groups including control, cadmium chloride, cadmium chloride + vit...