XIAOMEI GU: Physiopathology of Osteoclast in Bone (Under the direction of Dr. Eric T. Everett) Bone is constantly remodeled by osteoclastic bone resorption and osteoblastic bone formation. Abnormal remodeling can result in bone mass change; bone loss is implicated in a number of bone diseases, representing an increase in bone resorption relative to formation. Therefore, an understanding of oste...

Objective- Bone regeneration is a multifactorial phenomenon which contributed to several factors. It is reported that risedronate is effective for musculoskeletal diseases. The current study was to determine effectiveness of the risedronate-loaded nano capsules for calvaria healing in rabbit.Design- Experimental study.Procedures- 15 white adult male New Zealand rabbits were used. Fo...

Autoimmune diseases are an important field for the development of hematopoietic stem cell transplantation (HSCT). The Brazilian Society Cellular Therapy and Bone Marrow Transplantation (Sociedade Brasileira de Terapia Celular e Transplante Medula Óssea, SBTMO) organized consensus meetings Diseases Group, to review available literature on HSCT autoimmune diseases, aiming gather data that support...

Background: Celiac disease (CD), as an autoimmune disease has initiated since ingestion of food containing gluten. Constant intolerance to gluten causes damages of the small intestinal mucosa. One reason of mal-absorption in children and infants is CD. Additionally, about 75% of newly identified patients with CD have low bone mineral density (BMD). Many factors have role in metabolic bone disea...

multipotent mesenchymal stromal cells or mesenchymal stem cells (mscs) are mainly isolated from bone marrow or fat tissue. because of their potential of multilineage differentiation towards bone, cartilage and fat tissue, they were initially evaluated to develop innovative strategies for tissue engineering applications. more recently, they have gained interest based on their immunomodulatory pr...

Bone remodeling occurs at the bone surface throughout adult life and associates bony quantity and quality. This process is a balance between the osteoblastic bone formation and osteoclastic bone resorption, which cross-talks together. Semaphorin 3A is a membrane-associated secreted protein and regarded as a diffusible axonal chemorepellent, which has been identified in the involvement of bone r...

Characteristics of microscopic bone cross section images carry essential clues for defining the important features in the bone cross section such as harvesian canals, osteons, osteon fragments, lamellar bone, bony trabeculae, myxoid matrix and artifact for different age groups and also for age related developments & diseases. The traditional approaches of bone microscopic image analysis rely pr...

Characteristics of microscopic osteosarcoma bone cross section images carry essential clues for defining the important features in the bone cross section such as stroma, bone, malignant cell, myxoid matrix, artifact for different age groups and also for age related developments & diseases. The traditional approaches of bone microscopic image analysis rely primarily on manual processes with very...

Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such as osteopetrosis, which frequently results from defects in this process. Recent work has further dissected the role of the endolysosomal system in both bone formation by osteoblasts and bone resorption by osteoclasts. This pathway also plays an important role in the communication between these an...