نتایج جستجو برای: bmmscs
تعداد نتایج: 206 فیلتر نتایج به سال:
002 drugs against AD [7]. Bone marrow-derived mesenchymal stem cells (MSCs) were able to home on the injured brain and remove Abeta plaques from the hippocampus and to reduce Abeta deposits through the activation of endogenous microglia in an induced AD mouse model [8]. Human umbilical cord-derived MSCs have been shown to improve memory deficits, and reduce Abeta deposition [9]. Moreover, one r...
Introduction Periodontal tissue is a complete and complex system not only includes cementum/periodontal complex, but also periodontal/alveolar complex which is more significant for tooth regeneration. Numerous therapeutic measures have been utilized over the years in an attempt to achieve predicable periodontal regeneration. However, limitations of current regeneration modalities in both predic...
Subcutaneous transplants of bone marrow mesenchymal stem cells (BMMSCs) are capable of generating ectopic bone and organizing functional hematopoietic marrow elements in animal models. Here we report that immunocompromised mice received subcutaneous BMMSC transplants using hydroxyapatite tricalcium phosphate as a carrier suppressed age-related degeneration in multiple organs and benefited an in...
In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted central dogmas of commitment of ASCs by showing their plasticity to differentiate a...
Although stem-cell therapies have been suggested for cardiac-regeneration after myocardial-infarction (MI), key-questions regarding the in-vivo cell-fate remain unknown. While most available animal-models require immunosuppressive-therapy when applying human cells, the fetal-sheep being pre-immune until day 75 of gestation has been proposed for the in-vivo tracking of human cells after intra-pe...
Apilot study by Wu et al. (1) suggests that umbilical cordYderived mesenchymal stem cells (UCMSCs) promote hematopoietic engraftment when cotransplanted with cord blood (CB) cells (Fig. 1A). The authors make good use of two somatic stem cells, both derived from umbilical cord. Together with the establishment of their UCMSC bank, their trial appears to be potentially meaningful for future develo...
Myocardial ischaemia (MI) results in extensive cardiomyocyte death and reactive oxygen species (ROS)-induced damage in an organ with little or no regenerative capacity. Although the use of adult bone marrow mesenchymal stem cells (BMMSCs) has been proposed as a treatment option, the high cell numbers required for clinical use are difficult to achieve with this source of MSCs, and animal studies...
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