When news broke in 2001 that bone marrow– derived stem cells (BMCs) regenerate cardiac myocytes after myocardial infarction (MI), the prospects of regenerative therapy suddenly dawned on the horizon of cardiovascular medicine. Along with reports about differentiation of BMCs into neurons, hepatocytes, and muscle,1–4 BMCs delivered to the heart were shown to transdifferentiate into cardiac myocy...

We have developed a powerful bone marrow transplantation method, intra-bone marrow-bone marrow transplantation (IBM-BMT), in which donor BM cells (BMCs) are directly injected into the recipient’s BM, resulting in a rapid recovery of donor hematopoiesis and a reduction in the severity of GVHD. We subsequently developed more effective BMT protocols by modifying IBM-BMT. One method involves the si...

The use of Beneficial Microorganisms for Corals (BMCs) has been proposed recently as a tool the improvement coral health, with knowledge in this research topic advancing rapidly. BMCs are defined consortia microorganisms that contribute to health through mechanisms include ( a) promoting nutrition and growth, b) mitigating stress impacts toxic compounds, c) deterring pathogens, d) benefiting ea...

To determine the mechanism(s) by which interleukin-1 (IL-1) promotes granulopoiesis in vivo, we examined the effect of in vivo administration of IL-1 alpha on colony-stimulating factor (CSF) receptor expression on bone marrow cells (BMCs) and whether this directly correlated with progenitor cell responsiveness. Administration of IL-1 alpha to mice induced the upregulation of both granulocyte-ma...

This study assessed contributions of micron-scale topography on clinically relevant titanium (Ti) to differentiation of osteoprogenitor cells and osteoblasts; the interaction of this effect with 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3); and if the effects are sex-dependent. Male and female rat bone marrow cells (BMCs) were cultured on acid-etched (A, R a = 0.87 μm), grit-blasted (GB, R a = 3.90...

In this study, we investigated the therapeutic potential of bone marrow mononuclear cells (BMCs) in a model of epilepsy induced by pilocarpine in rats. BMCs obtained from green fluorescent protein (GFP) transgenic mice or rats were transplanted intravenously after induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale. All...

We have tested the ability of bone marrow (BM) cells (BMCs) to form hepatocytes in liver injury models. We used three models: (i) carbon tetrachloride (CCl4) treatment, (ii) albumin-urokinase transgenic mouse [TgN(Alb1Plau)], and (iii) hepatitis B transgenic mouse [TgN(Alb1HBV)]. As a nonselective liver injury model, irradiated C57BL/6 (B6) mice were transplanted with BMCs from GFP transgenic m...

OBJECTIVE To determine the frequency and characteristics of bifid mandibular condyle (BMC) using computed tomography (CT) evaluation. STUDY DESIGN A retrospective study was carried out using the CT records of 550 patients referred to the Medical School of Erciyes University (Kayseri, Turkey) between 2007 and 2010. T-tests were used to compare frequency of BMC between the left and right sides ...

RATIONALE Bone marrow-derived cells to treat myocardial injury improve cardiac function and support beneficial cardiac remodeling. However, survival of stem cells is limited due to low proliferation of transferred cells. OBJECTIVE To demonstrate long-term potential of c-kit(+) bone marrow stem cells (BMCs) enhanced with Pim-1 kinase to promote positive cardiac remodeling. METHODS AND RESULT...

14 Current research indicates that exogenous stem cells may accelerate reparative 15 processes in joint disease. However, no previous studies have evaluated whether bone marrow 16 cells (BMCs) target the injured cranial cruciate ligament (CCL) in dogs. The objective of this 17 study was to investigate engraftment of BMCs following intra-articular injection in dogs with 18 spontaneous CCL injury...