BACKGROUND AND AIM Despite improvements in surgical revascularisation, limitations like anatomical factors or atherosclerosis limit the success of revascularisation in diabetic patients with critical limb ischaemia. Stem cells were shown to improve microcirculation in published studies. The aim of this study was to evaluate safety, feasibility and efficacy of transplantation of bone marrow deri...

Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ significantly in progenitor cell content and lymphocyte dose, the clinical consequences of these differences with respect to engraftment, graft-ve...

BACKGROUND Although bone marrow-derived cells (BMCs) have shown great therapeutic potential in patients with chronic ischemic heart disease (CIHD), the exact efficacy and safety of BMCs therapy is still not completely defined. MATERIAL/METHODS We searched PubMed, OVID, EMBASE, the Cochrane Library, and ClinicalTrials.gov and finally identified 20 qualified trials in this meta-analysis. Assess...

Muscle aging is associated with changes in myeloid cell phenotype that may influence age-related changes in muscle structure. We tested whether preventing age-related reductions in muscle neuronal nitric oxide synthase (nNOS) would obviate age-related changes in myeloid cells in muscle. Our findings show that muscle aging is associated with elevations of anti-inflammatory M2a macrophages that c...

Submit Manuscript | http://medcraveonline.com Abbreviations: LCT: Lambda-Cyhalothrin; LD: Lethal Dose; NOAEL: No-Observed-Adverse-Effect Level; Con A: Concanavalin A; SRBCs: Sheep Red Blood Cells; WBCs: White Blood Cells; Ig: Immunoglobulin; HA: Hemagglutination; QHS: Quantitative Hemolysis of SRBCs; FCS: Fetal Calf Serum; DTH: Delayed-type of Hypersensitivity Response; BMCs: Blood Mononuclear ...

Because leukemia inhibitory factor (LIF) has little or no effect on murine hematopoietic progenitor cell growth yet enhances hematopoiesis in vivo, we sought to determine whether the effects of LIF were directly or indirectly mediated, or a combination of both. Although LIF alone or in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) has no effe...

BACKGROUND Recombinant expression of toxic proteins remains a challenging problem. One potential method to shield toxicity and thus improve expression of these proteins is to encapsulate them within protein compartments to sequester them away from their targets. Many bacteria naturally produce so-called bacterial microcompartments (BMCs) in which enzymes comprising a biosynthetic pathway are en...

Modern computer server systems are increasingly managed at a low level by baseboard management controllers (BMCs). BMCs processors with access to the most critical parts of platform, below OS or hypervisor, including control over power delivery every system component. Buggy poorly designed BMC software not only poses security threat machine, it can permanently render hardware inoperative. Despi...

Sports injuries and secondary joint problems, mainly of the knee, are common, especially in sports associated with high impact activities and/or torsional loading. The consequences can be career ending elite athletes reduce exercise recreational people. Various cell products injected intra-articularly. First, fresh cellular mixtures prepared same day, such as stromal vascular fraction adipose t...

BACKGROUND Intracoronary transfer of autologous bone marrow cells (BMCs) may enhance recovery of left ventricular (LV) function in patients after acute myocardial infarction (AMI). However, clinical studies addressing the effects of BMCs after AMI have covered only limited time frames ranging from 3 to 6 months. The critical question of whether BMC transfer can have a sustained impact on LV fun...