1. The major components of the blood fibrinolytic enzyme system were measured in patients with congestive cardiac failure, in control patients with heart disease but not in failure, and in control subjects without heart disease. 2. Heart disease in the absence of failure was associated with an increase in fibrinogen, fibrin degradation products and a,-antitrypsin, but not with any alteration of...

rDSPA alpha 1 (recombinant Desmodus salivary plasminogen activator alpha 1) is a recombinant protein corresponding to a natural plasminogen activator from the vampire bat Desmodus rotundus. The thrombolytic properties of rDSPA alpha 1 and tissue-type plasminogen activator (t-PA) were compared in a rat model of pulmonary embolism. Whole blood clots, produced in vitro and labeled with 125I-fibrin...

The fibrinolytic components of uterine arterial and venous blood were studied in 14 patients undergoing various obstetrical and gynaecological procedures. There was a highly significant higher concentration of plasminogen activator, as measured by the euglobulin lysis time, and fibrin degradation products in the uterine venous blood.

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background: escherichia coli (e. coli) is the most extensively used host for the production of recombinant proteins. however, most of the eukaryotic proteins are typically obtained as insoluble, misfolded inclusion bodies that need solubilization and refolding. reteplase as a highly disulfide-bonded recombinant protein is an example of difficult to express protein in e. coli. methods: in this s...

Notes of Original Lesion.t-A European male, aged 51, was admitted to hospital at 7 p.m. on February 11, 1952, within half an hour of being bitten by a viperine snake on the dorsum of the left foot (specimen identified as Echis carinatus). He was treated immediately by tourniquet and incisions of the bitten area under pentothal; 10 ml. antivenine were injected locally and 10 ml. intramuscularly....