BACKGROUND Dabigatran, a direct thrombin inhibitor, is indicated for the prevention and treatment of venous thromboembolism and for stroke prophylaxis in atrial fibrillation. The manufacturer recommends that dabigatran etexilate be retained in the original packaging until administration. Currently, no information exists about the stability of dabigatran etexilate outside its original packaging....

We created graphene blisters that cover and seal an annular cylinder-shaped microcavity in a SiO2 substrate filled with a gas. By controlling the pressure difference between the gas inside and outside of the microcavity, we switch the graphene membrane between multiple stable equilibrium configurations. We carried out experiments starting from the situation where the pressure of the gas inside ...

Bullous pemphigoid (BP) is an autoimmune skin disease characterized by the binding of autoantibodies to components of the hemidesmosome structure, resulting in an inflammatory response and subepidermal blister formation. To investigate the role of immune orientation in the inflammatory processes associated with disease progression, blister fluid, serum, and biopsy specimens were collected from ...

Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly immunodominant in BP. The structure and location of BP180 indicate that it is a significant autoantigen and plays a key role in blister formation. Autoantibodies from BP patients react with BP180, which leads to its degr...

OBJECTIVE To determine whether paper tape prevents foot blisters in multistage ultramarathon runners. DESIGN Multisite prospective randomized trial. SETTING The 2014 250-km (155-mile) 6-stage RacingThePlanet ultramarathons in Jordan, Gobi, Madagascar, and Atacama Deserts. PARTICIPANTS One hundred twenty-eight participants were enrolled: 19 (15%) from the Jordan, 35 (27%) from Gobi, 21 (16...

Delayed post‐burn blistering is an interesting and unusual phenomenon which has received little attention in the literature.[1,2] We herein report a case of a 20‐year‐old man who presented to the dermatology outpatient department with complaints of recurrent, apparently spontaneous blistering, occurring over a post‐ burn scar. The patient had sustained a thermal burn with accidental spillage of...

Electrophoretic analysis was used extensively in the 1970's to estimate genetic relationships among populations, species, and closely related genera of many different plants and animals, including many insect groups. Some of the first electrophoretic work on bark beetles was done by Anderson and others (1979), Anderson and others (1983), Florence and Kulhavy (1981), Florence and others (1982), ...

Inter-specific interactions are important drivers and maintainers of biodiversity. Compared to trophic and competitive interactions, the role of non-trophic facilitation among species has received less attention. Cavity-nesting bees nest in old beetle borings in dead wood, with restricted diameters corresponding to the body size of the bee species. The aim of this study was to test the hypothes...