Pulmonary fibrosis is a disease of significant morbidity, with no effective therapeutics and an as yet incompletely defined genetic basis. The chemotherapeutic agent bleomycin induces pulmonary fibrosis in susceptible C57BL/6J mice but not in mice of the C3H/HeJ strain, and this differential strain response has been used in prior studies to map bleomycin-induced pulmonary fibrosis susceptibilit...

Bleomycin-induced lung injury has been extensively used as a model of interstitial pneumonia and pulmonary fibrosis. Intercellular adhesion molecule (ICAM)-1 is a ligand for lymphocyte function-associated antigen (LFA)-1alpha and has been shown to be required for leukocyte migration into inflamed areas. The purpose of this report was to investigate the role of the ICAM-1/LFA-1alpha pathway in a...

INTRODUCTION The aim of this study was to investigate the effect of aerobic exercise (AE) in reducing bleomycin-induced fibrosis in mice of a Th2-dominant immune background (BALB/c). METHODS BALB/c mice were distributed into: sedentary, control (CON), Exercise-only (EX), sedentary, bleomycin-treated (BLEO) and bleomycin-treated+exercised (BLEO+EX); (n = 8/group). Following treadmill adaptatio...

We study the use of photochemical internalization (PCI) for enhancing chemotherapeutic response to malignant glioma cells in vitro. Two models are studied: monolayers consisting of F98 rat glioma cells and human glioma spheroids established from biopsy-derived glioma cells. In both cases, the cytotoxicity of aluminum phthalocyanine disulfonate (AlPcS2a)-based PCI of bleomycin was compared to Al...

Basigin is expressed in many tissues during development, including lung. It is also found on tumor cells and in wounds where it is thought to stimulate adjacent fibroblasts to produce matrix metalloproteinases. To investigate whether basigin might be expressed in fibro-inflammatory lung processes, we generated bleomycin-induced lung injury in mice. At 14 d after intratracheal bleomycin, we foun...

from june 1992 to march 1993, a group of patients suffering from different types of warts were treated with intralesional injections of bleomycin sulfate. this study reviews the literature concerning this modality of treatment and the pathophysiology and immunohistopathology of warts and options for treatment. in this prospective study, a combination of a i mg/ml solution of bleomycin in distil...

background: bleomycin (bl) is a glycopeptide antibiotic obtained from the bacterium streptomyces verticillus which is routinely used for treatment of human cancers. royal jelly (rj) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. rj consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. objective: the aim ...

Abstract Background Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy being investigated in trials for the treatment of PF patients. However, little known about underlying molecular and cellular mechanisms hucMSC on PF. In this study, behavior was bleomycin-induced mouse model. Methods The effec...

Background: Accumulation of fluid in pleural space, which is malignant nature, secondary to lung, breast or ovarian tumors. Metastatic Adeno Ca most commonly seen male and female. It indicates advanced disease reduced survival. Aim: Is study prospectively thirty patients with effusion according their clinical presentation, ways diagnosis, methods chemical pleurodesis. Patient methods: Data coll...

introduction: bleomycin sulfate is a dna damaging agent used in cancer chemotherapy. the effect of this drug on various cell cycle stages might be different, thus inducing different modes of death (apoptotic or mitotic death). the aim of this investigation was to study the effects of bleomycin on human peripheral blood lymphocytes at various cell cycle stages by two different end points (induct...