The objective of the work is to formulate, optimize and evaluate “Itraconazole nanosuspension as aerosol foam formulation” for the treatment of skin diseases such as Cellulitis, Erysipelas, Impeigo and Blastomycosis, Histoplasmosis, Onchomycosis, etc. The solubility of poorly soluble itraconazole can be improved through nanosuspension process and also the absorption rate and bioavailability of ...

Dermostatin is a polyene antibiotic which possesses a typical spectrum of antimicrobial activity. In vivo, by parenteral or oral administration, dermostatin was less effective than amphotericin B against Candida albicans. The in vivo activity of dermostatin was comparable to amphotericin B against Cryptococcus neoformans and Blastomyces dermatitidis ; amphotericin B was more effective than derm...

A 55-year-old male presented with back pain and slightly tender annular plaques with central ulceration on his face. A skin biopsy revealed scattered yeast with broad based buds. A CT scan of the abdomen revealed a pathologic T12 fracture. Tissue obtained from the spine confirmed budding yeasts. The patient was diagnosed with disseminated blastomycosis. The patient was treated with amphotericin...